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Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells

BACKGROUND: Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance...

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Detalles Bibliográficos
Autores principales:	Lucia, M B, Anu, R, Handley, M, Gillet, J-P, Wu, C-P, De Donatis, G M, Cauda, R, Gottesman, M M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170973/ https://www.ncbi.nlm.nih.gov/pubmed/21829205 http://dx.doi.org/10.1038/bjc.2011.275

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