Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

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Nuclear factor (NF)-κB, activated by IκB kinase (IKK), is a key regulator of inflammation, innate immunity, and tissue integrity. NF-κB and one of its main activators and transcriptional targets, tumor necrosis factor (TNF), are up-regulated in many inflammatory diseases that are accompanied by tiss...

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Detalles Bibliográficos
Autores principales: Guma, Monica, Stepniak, Dariusz, Shaked, Helena, Spehlmann, Martina E., Shenouda, Steve, Cheroutre, Hilde, Vicente-Suarez, Ildelfonso, Eckmann, Lars, Kagnoff, Martin F., Karin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171091/
https://www.ncbi.nlm.nih.gov/pubmed/21825016
http://dx.doi.org/10.1084/jem.20110242
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