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Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

OBJECTIVE: Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population. MATERIAL AND METHOD...

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Autores principales: Livshits, Gregory, Popham, Maria, Malkin, Ida, Sambrook, Philip N, MacGregor, Alex J, Spector, Timothy, Williams, Frances M K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171106/
https://www.ncbi.nlm.nih.gov/pubmed/21646416
http://dx.doi.org/10.1136/ard.2010.137836
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author Livshits, Gregory
Popham, Maria
Malkin, Ida
Sambrook, Philip N
MacGregor, Alex J
Spector, Timothy
Williams, Frances M K
author_facet Livshits, Gregory
Popham, Maria
Malkin, Ida
Sambrook, Philip N
MacGregor, Alex J
Spector, Timothy
Williams, Frances M K
author_sort Livshits, Gregory
collection PubMed
description OBJECTIVE: Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population. MATERIAL AND METHODS: A cross-sectional study was conducted among 2256 women (371 and 698 monozygotic and dizygotic twin pairs and 29 sibling pairs and 60 singletons) with a mean age of 50 years (18–84). A self-reported validated questionnaire was used to collect back pain data. Risk factors including body weight, smoking, occupation, physical exercise and MRI assessed LDD were measured. Data analysis included logistic regression and variance decomposition. RESULTS: The major factors associated with LBP included genetic background, with OR approximately 6 if the monozygotic co-twin had LBP, or 2.2 if she was a dizygotic co-twin. In addition, LDD and overweight were highly significantly (p<0.001) associated with non-specific LBP. The single most important risk factor was the amount of LDD. After adjustment for other risk factors, the individuals who exhibited advanced LDD (90% vs 10%) had 3.2 higher odds of manifesting LBP. The data also showed a significant (p<0.001) genetic correlation between the LBP and LDD measurements, suggesting that approximately 11–13% of the genetic effects are shared by LDD and LBP. CONCLUSIONS: The main risk factors for reported episodes of severe and disabling LBP in UK women include the degree of LDD as assessed by MRI, being overweight and genetic heritability.
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spelling pubmed-31711062011-09-19 Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study Livshits, Gregory Popham, Maria Malkin, Ida Sambrook, Philip N MacGregor, Alex J Spector, Timothy Williams, Frances M K Ann Rheum Dis Clinical and Epidemiological Research OBJECTIVE: Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population. MATERIAL AND METHODS: A cross-sectional study was conducted among 2256 women (371 and 698 monozygotic and dizygotic twin pairs and 29 sibling pairs and 60 singletons) with a mean age of 50 years (18–84). A self-reported validated questionnaire was used to collect back pain data. Risk factors including body weight, smoking, occupation, physical exercise and MRI assessed LDD were measured. Data analysis included logistic regression and variance decomposition. RESULTS: The major factors associated with LBP included genetic background, with OR approximately 6 if the monozygotic co-twin had LBP, or 2.2 if she was a dizygotic co-twin. In addition, LDD and overweight were highly significantly (p<0.001) associated with non-specific LBP. The single most important risk factor was the amount of LDD. After adjustment for other risk factors, the individuals who exhibited advanced LDD (90% vs 10%) had 3.2 higher odds of manifesting LBP. The data also showed a significant (p<0.001) genetic correlation between the LBP and LDD measurements, suggesting that approximately 11–13% of the genetic effects are shared by LDD and LBP. CONCLUSIONS: The main risk factors for reported episodes of severe and disabling LBP in UK women include the degree of LDD as assessed by MRI, being overweight and genetic heritability. BMJ Group 2011-06-06 /pmc/articles/PMC3171106/ /pubmed/21646416 http://dx.doi.org/10.1136/ard.2010.137836 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Clinical and Epidemiological Research
Livshits, Gregory
Popham, Maria
Malkin, Ida
Sambrook, Philip N
MacGregor, Alex J
Spector, Timothy
Williams, Frances M K
Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
title Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
title_full Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
title_fullStr Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
title_full_unstemmed Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
title_short Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
title_sort lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the uk twin spine study
topic Clinical and Epidemiological Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171106/
https://www.ncbi.nlm.nih.gov/pubmed/21646416
http://dx.doi.org/10.1136/ard.2010.137836
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