I[Image: see text]B, NF-[Image: see text]B Regulation Model: Simulation Analysis of Small Number of Molecules

The regulation of I[Image: see text]B, NF-[Image: see text]B is of foremost interest in biology as the transcription factor NF-[Image: see text]B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of I[Image: see text]B, NF-[Image: see text]B mathematic...

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Detalles Bibliográficos
Autores principales: Sarkar, Anamika, Meila, Marina, Franza, Robert B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171332/
https://www.ncbi.nlm.nih.gov/pubmed/18301714
http://dx.doi.org/10.1155/2007/25250
Descripción
Sumario:The regulation of I[Image: see text]B, NF-[Image: see text]B is of foremost interest in biology as the transcription factor NF-[Image: see text]B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of I[Image: see text]B, NF-[Image: see text]B mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF-[Image: see text]B oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied.

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