MiR-34a Targeting of Notch Ligand Delta-Like 1 Impairs CD15(+)/CD133(+) Tumor-Propagating Cells and Supports Neural Differentiation in Medulloblastoma

BACKGROUND: Through negative regulation of gene expression, microRNAs (miRNAs) can function as oncosuppressors in cancers, and can themselves show altered expression in various tumor types. Here, we have investigated medulloblastoma tumors (MBs), which arise from an early impairment of developmental...

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Detalles Bibliográficos
Autores principales: de Antonellis, Pasqualino, Medaglia, Chiara, Cusanelli, Emilio, Andolfo, Immacolata, Liguori, Lucia, De Vita, Gennaro, Carotenuto, Marianeve, Bello, Annamaria, Formiggini, Fabio, Galeone, Aldo, De Rosa, Giuseppe, Virgilio, Antonella, Scognamiglio, Immacolata, Sciro, Manuela, Basso, Giuseppe, Schulte, Johannes H., Cinalli, Giuseppe, Iolascon, Achille, Zollo, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171461/
https://www.ncbi.nlm.nih.gov/pubmed/21931765
http://dx.doi.org/10.1371/journal.pone.0024584

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