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Cigarette Smoke Extract (CSE) Delays NOD2 Expression and Affects NOD2/RIPK2 Interactions in Intestinal Epithelial Cells

BACKGROUND: Genetic and environmental factors influence susceptibility to Crohn's disease (CD): NOD2 is the strongest individual genetic determinant and smoking the best-characterised environmental factor. Carriage of NOD2 mutations predispose to small-intestinal, stricturing CD, a phenotype al...

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Detalles Bibliográficos
Autores principales:	Aldhous, Marian C., Soo, Kimberley, Stark, Lesley A., Ulanicka, Agata A., Easterbrook, Jennifer E., Dunlop, Malcolm G., Satsangi, Jack
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171477/ https://www.ncbi.nlm.nih.gov/pubmed/21931826 http://dx.doi.org/10.1371/journal.pone.0024715

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