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Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy
BACKGROUND: Studies have suggested that demographic and lifestyle factors could shape the composition of fecal microbiota in early life. This study evaluated infant stool microbiota signatures in two Asian populations, Singapore (n = 42) and Indonesia (n = 32) with contrasting socioeconomic developm...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171725/ https://www.ncbi.nlm.nih.gov/pubmed/21875444 http://dx.doi.org/10.1186/1471-2180-11-193 |
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author | Yap, Gaik Chin Chee, Kok Keong Hong, Pei-Ying Lay, Christophe Satria, Cahya D Sumadiono Soenarto, Yati Haksari, Ekawaty L Aw, Marion Shek, Lynette Pei-Chi Chua, Kaw Yan Zhao, Yudong Leow, Doreen Lee, Bee Wah |
author_facet | Yap, Gaik Chin Chee, Kok Keong Hong, Pei-Ying Lay, Christophe Satria, Cahya D Sumadiono Soenarto, Yati Haksari, Ekawaty L Aw, Marion Shek, Lynette Pei-Chi Chua, Kaw Yan Zhao, Yudong Leow, Doreen Lee, Bee Wah |
author_sort | Yap, Gaik Chin |
collection | PubMed |
description | BACKGROUND: Studies have suggested that demographic and lifestyle factors could shape the composition of fecal microbiota in early life. This study evaluated infant stool microbiota signatures in two Asian populations, Singapore (n = 42) and Indonesia (n = 32) with contrasting socioeconomic development, and examined the putative influences of demographic factors on these human fecal associated bacterial signatures. RESULTS: Longitudinal analysis showed associations of geographical origin with Clostridium leptum, Atopobium and Bifidobacterium groups. Mode of delivery had the largest effect on stool microbiota signatures influencing the abundance of four bacterial groups. Significantly higher abundance of bacterial members belonging to the Bacteroides-Prevotella, Bifidobacterium and Atopobium groups, but lower abundance of Lactobacilli-Enterococci group members, were observed in vaginal delivered compared to caesarean delivered infants. Demographic factors influencing the structure of infants stool microbiota during the first year of life included breastfeeding, age of weaning, sibship size and exposure to antibiotics. CONCLUSIONS: Differences in stool microbiota signatures were observed in relation to various demographic factors. These features may confound studies relating to the association of the structure of fecal microbiota and the predisposition to human modern disease. |
format | Online Article Text |
id | pubmed-3171725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31717252011-09-13 Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy Yap, Gaik Chin Chee, Kok Keong Hong, Pei-Ying Lay, Christophe Satria, Cahya D Sumadiono Soenarto, Yati Haksari, Ekawaty L Aw, Marion Shek, Lynette Pei-Chi Chua, Kaw Yan Zhao, Yudong Leow, Doreen Lee, Bee Wah BMC Microbiol Research Article BACKGROUND: Studies have suggested that demographic and lifestyle factors could shape the composition of fecal microbiota in early life. This study evaluated infant stool microbiota signatures in two Asian populations, Singapore (n = 42) and Indonesia (n = 32) with contrasting socioeconomic development, and examined the putative influences of demographic factors on these human fecal associated bacterial signatures. RESULTS: Longitudinal analysis showed associations of geographical origin with Clostridium leptum, Atopobium and Bifidobacterium groups. Mode of delivery had the largest effect on stool microbiota signatures influencing the abundance of four bacterial groups. Significantly higher abundance of bacterial members belonging to the Bacteroides-Prevotella, Bifidobacterium and Atopobium groups, but lower abundance of Lactobacilli-Enterococci group members, were observed in vaginal delivered compared to caesarean delivered infants. Demographic factors influencing the structure of infants stool microbiota during the first year of life included breastfeeding, age of weaning, sibship size and exposure to antibiotics. CONCLUSIONS: Differences in stool microbiota signatures were observed in relation to various demographic factors. These features may confound studies relating to the association of the structure of fecal microbiota and the predisposition to human modern disease. BioMed Central 2011-08-26 /pmc/articles/PMC3171725/ /pubmed/21875444 http://dx.doi.org/10.1186/1471-2180-11-193 Text en Copyright ©2011 Yap et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yap, Gaik Chin Chee, Kok Keong Hong, Pei-Ying Lay, Christophe Satria, Cahya D Sumadiono Soenarto, Yati Haksari, Ekawaty L Aw, Marion Shek, Lynette Pei-Chi Chua, Kaw Yan Zhao, Yudong Leow, Doreen Lee, Bee Wah Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy |
title | Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy |
title_full | Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy |
title_fullStr | Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy |
title_full_unstemmed | Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy |
title_short | Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy |
title_sort | evaluation of stool microbiota signatures in two cohorts of asian (singapore and indonesia) newborns at risk of atopy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171725/ https://www.ncbi.nlm.nih.gov/pubmed/21875444 http://dx.doi.org/10.1186/1471-2180-11-193 |
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