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An Overlapping Syndrome of Allergy and Immune Deficiency in Children
Recurrent airway inflammations in children are an important clinical problem in pediatric practice. An essential challenge is differentiation between allergic background and immune deficiency, which is a difficult task taking into consideration individual predisposition to atopy, immune system matur...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171763/ https://www.ncbi.nlm.nih.gov/pubmed/21918651 http://dx.doi.org/10.1155/2012/658279 |
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author | Szczawinska-Poplonyk, Aleksandra |
author_facet | Szczawinska-Poplonyk, Aleksandra |
author_sort | Szczawinska-Poplonyk, Aleksandra |
collection | PubMed |
description | Recurrent airway inflammations in children are an important clinical problem in pediatric practice. An essential challenge is differentiation between allergic background and immune deficiency, which is a difficult task taking into consideration individual predisposition to atopy, immune system maturation in the early childhood, as well as exposition to environmental allergens and microbial antigens. In this paper relationship between selected elements of innate and adaptive immunity, such as pattern-recognition receptors, complement components, dendritic cells, as well as immunoglobulins, and regulatory T lymph cells has been discussed. Particular attention has been paid to these mechanisms of the immune response which, depending on settings and timing of activation, predispose to allergy or contribute to tolerogenic phenotype. In the context of multifactorial conditioning of the innate and adaptive immunity governing the ultimate response and associations between allergy and immune deficiencies, these phenomena should be considered as pathogenetically not precluding, but as an overlapping syndrome. |
format | Online Article Text |
id | pubmed-3171763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31717632011-09-14 An Overlapping Syndrome of Allergy and Immune Deficiency in Children Szczawinska-Poplonyk, Aleksandra J Allergy (Cairo) Review Article Recurrent airway inflammations in children are an important clinical problem in pediatric practice. An essential challenge is differentiation between allergic background and immune deficiency, which is a difficult task taking into consideration individual predisposition to atopy, immune system maturation in the early childhood, as well as exposition to environmental allergens and microbial antigens. In this paper relationship between selected elements of innate and adaptive immunity, such as pattern-recognition receptors, complement components, dendritic cells, as well as immunoglobulins, and regulatory T lymph cells has been discussed. Particular attention has been paid to these mechanisms of the immune response which, depending on settings and timing of activation, predispose to allergy or contribute to tolerogenic phenotype. In the context of multifactorial conditioning of the innate and adaptive immunity governing the ultimate response and associations between allergy and immune deficiencies, these phenomena should be considered as pathogenetically not precluding, but as an overlapping syndrome. Hindawi Publishing Corporation 2012 2011-09-12 /pmc/articles/PMC3171763/ /pubmed/21918651 http://dx.doi.org/10.1155/2012/658279 Text en Copyright © 2012 Aleksandra Szczawinska-Poplonyk. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Szczawinska-Poplonyk, Aleksandra An Overlapping Syndrome of Allergy and Immune Deficiency in Children |
title | An Overlapping Syndrome of Allergy and Immune Deficiency in Children |
title_full | An Overlapping Syndrome of Allergy and Immune Deficiency in Children |
title_fullStr | An Overlapping Syndrome of Allergy and Immune Deficiency in Children |
title_full_unstemmed | An Overlapping Syndrome of Allergy and Immune Deficiency in Children |
title_short | An Overlapping Syndrome of Allergy and Immune Deficiency in Children |
title_sort | overlapping syndrome of allergy and immune deficiency in children |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171763/ https://www.ncbi.nlm.nih.gov/pubmed/21918651 http://dx.doi.org/10.1155/2012/658279 |
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