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No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis
In clinical studies of statins (class of drugs lowering plasma cholesterol levels), transient low-molecular-weight proteinuria was observed. The causes of statin-induced proteinuria in the patient background of those studies (cardiovascular and kidney disease) are multifactorial and, therefore, a ma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171927/ https://www.ncbi.nlm.nih.gov/pubmed/21918593 http://dx.doi.org/10.1155/2011/456076 |
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author | Verhulst, Anja Geryl, Hilde D'Haese, Patrick |
author_facet | Verhulst, Anja Geryl, Hilde D'Haese, Patrick |
author_sort | Verhulst, Anja |
collection | PubMed |
description | In clinical studies of statins (class of drugs lowering plasma cholesterol levels), transient low-molecular-weight proteinuria was observed. The causes of statin-induced proteinuria in the patient background of those studies (cardiovascular and kidney disease) are multifactorial and, therefore, a matter of debate. In light of this, it seemed interesting to investigate the effect of statins on the urinary protein concentration and proteome in healthy volunteers. Six healthy volunteers were randomly treated with rosuvastatin (40 mg/day) or pravastatin (80 mg/day) in a double-blinded cross-over study. Total urinary protein concentration and the concentration of albumin/retinol-binding protein were analysed, after which the urinary proteome was investigated. From the results described in this study, it was concluded that statins do not induce major changes in the urinary protein concentration/proteome. High variability in the baseline urinary proteome/proteins among volunteers, however, made it very difficult to find subtle (possibly isolated to individuals) effects of statins. |
format | Online Article Text |
id | pubmed-3171927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31719272011-09-14 No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis Verhulst, Anja Geryl, Hilde D'Haese, Patrick J Biomed Biotechnol Research Article In clinical studies of statins (class of drugs lowering plasma cholesterol levels), transient low-molecular-weight proteinuria was observed. The causes of statin-induced proteinuria in the patient background of those studies (cardiovascular and kidney disease) are multifactorial and, therefore, a matter of debate. In light of this, it seemed interesting to investigate the effect of statins on the urinary protein concentration and proteome in healthy volunteers. Six healthy volunteers were randomly treated with rosuvastatin (40 mg/day) or pravastatin (80 mg/day) in a double-blinded cross-over study. Total urinary protein concentration and the concentration of albumin/retinol-binding protein were analysed, after which the urinary proteome was investigated. From the results described in this study, it was concluded that statins do not induce major changes in the urinary protein concentration/proteome. High variability in the baseline urinary proteome/proteins among volunteers, however, made it very difficult to find subtle (possibly isolated to individuals) effects of statins. Hindawi Publishing Corporation 2011 2011-09-13 /pmc/articles/PMC3171927/ /pubmed/21918593 http://dx.doi.org/10.1155/2011/456076 Text en Copyright © 2011 Anja Verhulst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Verhulst, Anja Geryl, Hilde D'Haese, Patrick No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis |
title | No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis |
title_full | No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis |
title_fullStr | No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis |
title_full_unstemmed | No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis |
title_short | No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis |
title_sort | no evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171927/ https://www.ncbi.nlm.nih.gov/pubmed/21918593 http://dx.doi.org/10.1155/2011/456076 |
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