A Gastric Pathogen Moves Chemotaxis in a New Direction

For almost 50 years, Escherichia coli has been the model for understanding how bacteria orient their movement in response to chemical cues, but recent studies of chemotaxis in other bacteria have revealed interesting variations from prevailing paradigms. Investigating the human pathogen Helicobacter...

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Detalles Bibliográficos
Autores principales: Sweeney, Emily Goers, Guillemin, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171985/
https://www.ncbi.nlm.nih.gov/pubmed/21933915
http://dx.doi.org/10.1128/mBio.00201-11
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author Sweeney, Emily Goers
Guillemin, Karen
author_facet Sweeney, Emily Goers
Guillemin, Karen
author_sort Sweeney, Emily Goers
collection PubMed
description For almost 50 years, Escherichia coli has been the model for understanding how bacteria orient their movement in response to chemical cues, but recent studies of chemotaxis in other bacteria have revealed interesting variations from prevailing paradigms. Investigating the human pathogen Helicobacter pylori, Amieva and colleagues [mBio 2(4):e00098-11, 2011] discovered a new chemotaxis regulator, ChePep, which modulates swimming behavior through the canonical histidine-aspartate phosphorelay system. Functionally conserved among the epsilonproteobacteria, ChePep is essential for H. pylori to navigate deep into the stomach’s gastric glands and may be an attractive target for novel antibiotics.
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spelling pubmed-31719852011-09-20 A Gastric Pathogen Moves Chemotaxis in a New Direction Sweeney, Emily Goers Guillemin, Karen mBio Commentary For almost 50 years, Escherichia coli has been the model for understanding how bacteria orient their movement in response to chemical cues, but recent studies of chemotaxis in other bacteria have revealed interesting variations from prevailing paradigms. Investigating the human pathogen Helicobacter pylori, Amieva and colleagues [mBio 2(4):e00098-11, 2011] discovered a new chemotaxis regulator, ChePep, which modulates swimming behavior through the canonical histidine-aspartate phosphorelay system. Functionally conserved among the epsilonproteobacteria, ChePep is essential for H. pylori to navigate deep into the stomach’s gastric glands and may be an attractive target for novel antibiotics. American Society of Microbiology 2011-09-20 /pmc/articles/PMC3171985/ /pubmed/21933915 http://dx.doi.org/10.1128/mBio.00201-11 Text en Copyright © 2011 Sweeney and Guillemin. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Commentary
Sweeney, Emily Goers
Guillemin, Karen
A Gastric Pathogen Moves Chemotaxis in a New Direction
title A Gastric Pathogen Moves Chemotaxis in a New Direction
title_full A Gastric Pathogen Moves Chemotaxis in a New Direction
title_fullStr A Gastric Pathogen Moves Chemotaxis in a New Direction
title_full_unstemmed A Gastric Pathogen Moves Chemotaxis in a New Direction
title_short A Gastric Pathogen Moves Chemotaxis in a New Direction
title_sort gastric pathogen moves chemotaxis in a new direction
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171985/
https://www.ncbi.nlm.nih.gov/pubmed/21933915
http://dx.doi.org/10.1128/mBio.00201-11
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