FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE

A 31 years old man with history of familial psychiatric disorder was investigated. Chromosomal analysis in peripheral lymphocyte blood culture showed normal karyotype with 46, XY chromosomal complement. However, the cells treated with 5-Fluoro-deoxy-uridine (FUdR) and Caffeine showed fragile Xq-27 (...

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Detalles Bibliográficos
Autores principales: Murthy, S.K., Kar, Bibhas, Vaya, Lalit, Murthy, D.S. Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 1989
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172024/
https://www.ncbi.nlm.nih.gov/pubmed/21927411
Descripción
Sumario:A 31 years old man with history of familial psychiatric disorder was investigated. Chromosomal analysis in peripheral lymphocyte blood culture showed normal karyotype with 46, XY chromosomal complement. However, the cells treated with 5-Fluoro-deoxy-uridine (FUdR) and Caffeine showed fragile Xq-27 (4.0%) and nonspecific autosomal breakages (42.0%). The present case suggests a probable association between chromosomal fragility and non-mental retardation psychopathology. Further cytogenetic studies in cases with familial psychiatric disorders will enable us with a better understanding of the pathogenesis and further help in counselling the families.

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