FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE

A 31 years old man with history of familial psychiatric disorder was investigated. Chromosomal analysis in peripheral lymphocyte blood culture showed normal karyotype with 46, XY chromosomal complement. However, the cells treated with 5-Fluoro-deoxy-uridine (FUdR) and Caffeine showed fragile Xq-27 (...

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Detalles Bibliográficos
Autores principales: Murthy, S.K., Kar, Bibhas, Vaya, Lalit, Murthy, D.S. Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 1989
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172024/
https://www.ncbi.nlm.nih.gov/pubmed/21927411
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author Murthy, S.K.
Kar, Bibhas
Vaya, Lalit
Murthy, D.S. Krishna
author_facet Murthy, S.K.
Kar, Bibhas
Vaya, Lalit
Murthy, D.S. Krishna
author_sort Murthy, S.K.
collection PubMed
description A 31 years old man with history of familial psychiatric disorder was investigated. Chromosomal analysis in peripheral lymphocyte blood culture showed normal karyotype with 46, XY chromosomal complement. However, the cells treated with 5-Fluoro-deoxy-uridine (FUdR) and Caffeine showed fragile Xq-27 (4.0%) and nonspecific autosomal breakages (42.0%). The present case suggests a probable association between chromosomal fragility and non-mental retardation psychopathology. Further cytogenetic studies in cases with familial psychiatric disorders will enable us with a better understanding of the pathogenesis and further help in counselling the families.
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spelling pubmed-31720242011-09-16 FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE Murthy, S.K. Kar, Bibhas Vaya, Lalit Murthy, D.S. Krishna Indian J Psychiatry Case Report A 31 years old man with history of familial psychiatric disorder was investigated. Chromosomal analysis in peripheral lymphocyte blood culture showed normal karyotype with 46, XY chromosomal complement. However, the cells treated with 5-Fluoro-deoxy-uridine (FUdR) and Caffeine showed fragile Xq-27 (4.0%) and nonspecific autosomal breakages (42.0%). The present case suggests a probable association between chromosomal fragility and non-mental retardation psychopathology. Further cytogenetic studies in cases with familial psychiatric disorders will enable us with a better understanding of the pathogenesis and further help in counselling the families. Medknow Publications 1989 /pmc/articles/PMC3172024/ /pubmed/21927411 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Murthy, S.K.
Kar, Bibhas
Vaya, Lalit
Murthy, D.S. Krishna
FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE
title FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE
title_full FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE
title_fullStr FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE
title_full_unstemmed FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE
title_short FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE
title_sort fragile xq-27 associated with schizophrenia and familial psychosis an a male
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172024/
https://www.ncbi.nlm.nih.gov/pubmed/21927411
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