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ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

DNA polymerase η (polη) belongs to the Y-family of DNA polymerases and facilitates translesion synthesis past UV damage. We show that, after UV irradiation, polη becomes phosphorylated at Ser601 by the ataxia-telangiectasia mutated and Rad3-related (ATR) kinase. DNA damage–induced phosphorylation of...

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Detalles Bibliográficos
Autores principales:	Göhler, Thomas, Sabbioneda, Simone, Green, Catherine M., Lehmann, Alan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172178/ https://www.ncbi.nlm.nih.gov/pubmed/21242293 http://dx.doi.org/10.1083/jcb.201008076

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