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Egr-1 Induces a Profibrotic Injury/Repair Gene Program Associated with Systemic Sclerosis

Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor with key roles in mediating fibrotic TGF-ß re...

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Detalles Bibliográficos
Autores principales:	Bhattacharyya, Swati, Sargent, Jennifer L., Du, Pan, Lin, Simon, Tourtellotte, Warren G., Takehara, Kazuhiko, Whitfield, Michael L., Varga, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172216/ https://www.ncbi.nlm.nih.gov/pubmed/21931594 http://dx.doi.org/10.1371/journal.pone.0023082

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