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S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells

The calcium-binding protein S100A4 is a central mediator of metastasis formation in colon cancer. S100A4 is a target gene of the Wnt/β-catenin pathway, which is constitutively active in the majority of colon cancers. In this study a high-throughput screen was performed to identify small-molecule com...

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Detalles Bibliográficos
Autores principales:	Sack, Ulrike, Walther, Wolfgang, Scudiero, Dominic, Selby, Mike, Aumann, Jutta, Lemos, Clara, Fichtner, Iduna, Schlag, Peter M., Shoemaker, Robert H., Stein, Ulrike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172260/ https://www.ncbi.nlm.nih.gov/pubmed/21795396 http://dx.doi.org/10.1091/mbc.E10-09-0739

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