Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells

Hepatitis C virus (HCV) is a highly pathogenic human virus associated with liver fibrosis, steatosis, and cancer. In infected cells HCV induces oxidative stress. Here, we show that HCV proteins core, E1, E2, NS4B, and NS5A activate antioxidant defense Nrf2/ARE pathway via several independent mechani...

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Detalles Bibliográficos
Autores principales: Ivanov, Alexander V., Smirnova, Olga A., Ivanova, Olga N., Masalova, Olga V., Kochetkov, Sergey N., Isaguliants, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172309/
https://www.ncbi.nlm.nih.gov/pubmed/21931870
http://dx.doi.org/10.1371/journal.pone.0024957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172309/
https://www.ncbi.nlm.nih.gov/pubmed/21931870
http://dx.doi.org/10.1371/journal.pone.0024957

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