Notch3 Is Dispensable for Thymocyte β-Selection and Notch1-Induced T Cell Leukemogenesis

Notch1 (N1) signaling induced by intrathymic Delta-like (DL) ligands is required for T cell lineage commitment as well as self-renewal during “β-selection” of TCRβ(+) CD4(−)CD8(−) double negative 3 (DN3) T cell progenitors. However, over-expression of the N1 intracellular domain (ICN1) renders N1 ac...

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Detalles Bibliográficos
Autores principales: Suliman, Sara, Tan, Joanne, Xu, Keli, Kousis, Philaretos C., Kowalski, Paul E., Chang, Greg, Egan, Sean E., Guidos, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172312/
https://www.ncbi.nlm.nih.gov/pubmed/21931869
http://dx.doi.org/10.1371/journal.pone.0024937

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