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Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor

Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5′-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational an...

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Detalles Bibliográficos
Autores principales:	Moreau, Christelle, Ashamu, Gloria A., Bailey, Victoria C., Galione, Antony, Guse, Andreas H., Potter, Barry V. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2011
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172588/ https://www.ncbi.nlm.nih.gov/pubmed/20976353 http://dx.doi.org/10.1039/c0ob00396d

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