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Meta-analysis of genome-wide association for migraine in six population-based European cohorts
Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch–Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migra...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172930/ https://www.ncbi.nlm.nih.gov/pubmed/21448238 http://dx.doi.org/10.1038/ejhg.2011.48 |
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author | Ligthart, Lannie de Vries, Boukje Smith, Albert V Ikram, M Arfan Amin, Najaf Hottenga, Jouke-Jan Koelewijn, Stephany C Kattenberg, V Mathijs de Moor, Marleen HM Janssens, A Cecile JW Aulchenko, Yurii S Oostra, Ben A de Geus, Eco JC Smit, Johannes H Zitman, Frans G Uitterlinden, André G Hofman, Albert Willemsen, Gonneke Nyholt, Dale R Montgomery, Grant W Terwindt, Gisela M Gudnason, Vilmundur Penninx, Brenda WJH Breteler, Monique Ferrari, Michel D Launer, Lenore J van Duijn, Cornelia M van den Maagdenberg, Arn MJM Boomsma, Dorret I |
author_facet | Ligthart, Lannie de Vries, Boukje Smith, Albert V Ikram, M Arfan Amin, Najaf Hottenga, Jouke-Jan Koelewijn, Stephany C Kattenberg, V Mathijs de Moor, Marleen HM Janssens, A Cecile JW Aulchenko, Yurii S Oostra, Ben A de Geus, Eco JC Smit, Johannes H Zitman, Frans G Uitterlinden, André G Hofman, Albert Willemsen, Gonneke Nyholt, Dale R Montgomery, Grant W Terwindt, Gisela M Gudnason, Vilmundur Penninx, Brenda WJH Breteler, Monique Ferrari, Michel D Launer, Lenore J van Duijn, Cornelia M van den Maagdenberg, Arn MJM Boomsma, Dorret I |
author_sort | Ligthart, Lannie |
collection | PubMed |
description | Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch–Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migraine cohorts with a total sample size of 10 980 individuals (2446 cases and 8534 controls). A total of 32 SNPs showed marginal evidence for association at a P-value<10(−5). The best result was obtained for SNP rs9908234, which had a P-value of 8.00 × 10(−8). This top SNP is located in the nerve growth factor receptor (NGFR) gene. However, this SNP did not replicate in three cohorts from the Netherlands and Australia. Of the other 31 SNPs, 18 SNPs were tested in two replication cohorts, but none replicated. In addition, we explored previously identified candidate genes in the meta-analysis data set. This revealed a modest gene-based significant association between migraine and the metadherin (MTDH) gene, previously identified in the first clinic-based GWA study (GWAS) for migraine (Bonferroni-corrected gene-based P-value=0.026). This finding is consistent with the involvement of the glutamate pathway in migraine. Additional research is necessary to further confirm the involvement of glutamate. |
format | Online Article Text |
id | pubmed-3172930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-31729302011-09-19 Meta-analysis of genome-wide association for migraine in six population-based European cohorts Ligthart, Lannie de Vries, Boukje Smith, Albert V Ikram, M Arfan Amin, Najaf Hottenga, Jouke-Jan Koelewijn, Stephany C Kattenberg, V Mathijs de Moor, Marleen HM Janssens, A Cecile JW Aulchenko, Yurii S Oostra, Ben A de Geus, Eco JC Smit, Johannes H Zitman, Frans G Uitterlinden, André G Hofman, Albert Willemsen, Gonneke Nyholt, Dale R Montgomery, Grant W Terwindt, Gisela M Gudnason, Vilmundur Penninx, Brenda WJH Breteler, Monique Ferrari, Michel D Launer, Lenore J van Duijn, Cornelia M van den Maagdenberg, Arn MJM Boomsma, Dorret I Eur J Hum Genet Article Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch–Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migraine cohorts with a total sample size of 10 980 individuals (2446 cases and 8534 controls). A total of 32 SNPs showed marginal evidence for association at a P-value<10(−5). The best result was obtained for SNP rs9908234, which had a P-value of 8.00 × 10(−8). This top SNP is located in the nerve growth factor receptor (NGFR) gene. However, this SNP did not replicate in three cohorts from the Netherlands and Australia. Of the other 31 SNPs, 18 SNPs were tested in two replication cohorts, but none replicated. In addition, we explored previously identified candidate genes in the meta-analysis data set. This revealed a modest gene-based significant association between migraine and the metadherin (MTDH) gene, previously identified in the first clinic-based GWA study (GWAS) for migraine (Bonferroni-corrected gene-based P-value=0.026). This finding is consistent with the involvement of the glutamate pathway in migraine. Additional research is necessary to further confirm the involvement of glutamate. Nature Publishing Group 2011-08 2011-03-30 /pmc/articles/PMC3172930/ /pubmed/21448238 http://dx.doi.org/10.1038/ejhg.2011.48 Text en Copyright © 2011 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Ligthart, Lannie de Vries, Boukje Smith, Albert V Ikram, M Arfan Amin, Najaf Hottenga, Jouke-Jan Koelewijn, Stephany C Kattenberg, V Mathijs de Moor, Marleen HM Janssens, A Cecile JW Aulchenko, Yurii S Oostra, Ben A de Geus, Eco JC Smit, Johannes H Zitman, Frans G Uitterlinden, André G Hofman, Albert Willemsen, Gonneke Nyholt, Dale R Montgomery, Grant W Terwindt, Gisela M Gudnason, Vilmundur Penninx, Brenda WJH Breteler, Monique Ferrari, Michel D Launer, Lenore J van Duijn, Cornelia M van den Maagdenberg, Arn MJM Boomsma, Dorret I Meta-analysis of genome-wide association for migraine in six population-based European cohorts |
title | Meta-analysis of genome-wide association for migraine in six population-based European cohorts |
title_full | Meta-analysis of genome-wide association for migraine in six population-based European cohorts |
title_fullStr | Meta-analysis of genome-wide association for migraine in six population-based European cohorts |
title_full_unstemmed | Meta-analysis of genome-wide association for migraine in six population-based European cohorts |
title_short | Meta-analysis of genome-wide association for migraine in six population-based European cohorts |
title_sort | meta-analysis of genome-wide association for migraine in six population-based european cohorts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172930/ https://www.ncbi.nlm.nih.gov/pubmed/21448238 http://dx.doi.org/10.1038/ejhg.2011.48 |
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