Cargando…
Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates?
OBJECTIVES: Brain metastases (BMs) often advance the course of non-small cell lung cancer (NSCLC). We performed an observational study in order to investigate the possible correlation of selected clinical and epidemiological factors with BM appearance in patients suffering from different histologica...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173018/ https://www.ncbi.nlm.nih.gov/pubmed/21931502 http://dx.doi.org/10.2147/CMR.S22717 |
_version_ | 1782211925515436032 |
---|---|
author | Dimitropoulos, Charalampos Hillas, Georgios Nikolakopoulou, Sofia Kostara, Ioanna Sagris, Konstantinos Vlastos, Fotis Alchanatis, Manos |
author_facet | Dimitropoulos, Charalampos Hillas, Georgios Nikolakopoulou, Sofia Kostara, Ioanna Sagris, Konstantinos Vlastos, Fotis Alchanatis, Manos |
author_sort | Dimitropoulos, Charalampos |
collection | PubMed |
description | OBJECTIVES: Brain metastases (BMs) often advance the course of non-small cell lung cancer (NSCLC). We performed an observational study in order to investigate the possible correlation of selected clinical and epidemiological factors with BM appearance in patients suffering from different histological subtypes of NSCLC stage I–IV. METHODS: The study included 161 consecutive patients with NSCLC. Analyzed data included patient- and tumor-related characteristics. RESULTS: Thirty-nine patients (24.2%) presented BMs within 12 (0–36) weeks of diagnosis. BMs decreased the mean overall survival significantly (15.6 versus 50.7 weeks, P < 0.001), with hazard ratio (95% confidence interval) 3.60 (2.42–5.35). The age of the patients with BM was significantly lower than that of the patients without BM (60.8 ± 8.9 versus 66.5 ± 8.5, P < 0.001). Patients with BM had significantly higher pack-years consumption (75.9 ± 23.9 versus 58.9 ± 31.9, P = 0.003) and larger tumor size compared with patients without BM (size in mm: 55.1 ± 20.1 versus 45.9 ± 19.3, P = 0.012). The presence of BM was also correlated with the absence of lung (P < 0.001), bone (P = 0.005), and adrenal (P = 0.046) metastases. CONCLUSION: Younger NSCLC patients with high tobacco consumption, large tumor size, and absence of metastases in other organs (lung, bones, adrenal metastases) are at high risk of BM appearance during the course of NSCLC and are candidates for prophylactic cranial irradiation early in the course of the disease. |
format | Online Article Text |
id | pubmed-3173018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31730182011-09-19 Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? Dimitropoulos, Charalampos Hillas, Georgios Nikolakopoulou, Sofia Kostara, Ioanna Sagris, Konstantinos Vlastos, Fotis Alchanatis, Manos Cancer Manag Res Original Research OBJECTIVES: Brain metastases (BMs) often advance the course of non-small cell lung cancer (NSCLC). We performed an observational study in order to investigate the possible correlation of selected clinical and epidemiological factors with BM appearance in patients suffering from different histological subtypes of NSCLC stage I–IV. METHODS: The study included 161 consecutive patients with NSCLC. Analyzed data included patient- and tumor-related characteristics. RESULTS: Thirty-nine patients (24.2%) presented BMs within 12 (0–36) weeks of diagnosis. BMs decreased the mean overall survival significantly (15.6 versus 50.7 weeks, P < 0.001), with hazard ratio (95% confidence interval) 3.60 (2.42–5.35). The age of the patients with BM was significantly lower than that of the patients without BM (60.8 ± 8.9 versus 66.5 ± 8.5, P < 0.001). Patients with BM had significantly higher pack-years consumption (75.9 ± 23.9 versus 58.9 ± 31.9, P = 0.003) and larger tumor size compared with patients without BM (size in mm: 55.1 ± 20.1 versus 45.9 ± 19.3, P = 0.012). The presence of BM was also correlated with the absence of lung (P < 0.001), bone (P = 0.005), and adrenal (P = 0.046) metastases. CONCLUSION: Younger NSCLC patients with high tobacco consumption, large tumor size, and absence of metastases in other organs (lung, bones, adrenal metastases) are at high risk of BM appearance during the course of NSCLC and are candidates for prophylactic cranial irradiation early in the course of the disease. Dove Medical Press 2011-08-17 /pmc/articles/PMC3173018/ /pubmed/21931502 http://dx.doi.org/10.2147/CMR.S22717 Text en © 2011 Dimitropoulos et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Dimitropoulos, Charalampos Hillas, Georgios Nikolakopoulou, Sofia Kostara, Ioanna Sagris, Konstantinos Vlastos, Fotis Alchanatis, Manos Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? |
title | Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? |
title_full | Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? |
title_fullStr | Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? |
title_full_unstemmed | Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? |
title_short | Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? |
title_sort | prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173018/ https://www.ncbi.nlm.nih.gov/pubmed/21931502 http://dx.doi.org/10.2147/CMR.S22717 |
work_keys_str_mv | AT dimitropouloscharalampos prophylacticcranialirradiationinnonsmallcelllungcancerpatientswhomightbethecandidates AT hillasgeorgios prophylacticcranialirradiationinnonsmallcelllungcancerpatientswhomightbethecandidates AT nikolakopoulousofia prophylacticcranialirradiationinnonsmallcelllungcancerpatientswhomightbethecandidates AT kostaraioanna prophylacticcranialirradiationinnonsmallcelllungcancerpatientswhomightbethecandidates AT sagriskonstantinos prophylacticcranialirradiationinnonsmallcelllungcancerpatientswhomightbethecandidates AT vlastosfotis prophylacticcranialirradiationinnonsmallcelllungcancerpatientswhomightbethecandidates AT alchanatismanos prophylacticcranialirradiationinnonsmallcelllungcancerpatientswhomightbethecandidates |