Use of biotin targeted methotrexate–human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy

Biotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA. MTX-HSA nanoparticles (MTX-HSA N...

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Detalles Bibliográficos
Autores principales: Taheri, Azade, Dinarvand, Rassoul, Nouri, Faranak Salman, Khorramizadeh, Mohammad Reza, Borougeni, Atefeh Taheri, Mansoori, Pooria, Atyabi, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173049/
https://www.ncbi.nlm.nih.gov/pubmed/21931482
http://dx.doi.org/10.2147/IJN.S23949

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