Cargando…

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating

STIM1 and Orai represent the key components of Ca(2+) release-activated Ca(2+) channels. Activation of Orai channels requires coupling of the C terminus of STIM1 to the N and C termini of Orai. Although the latter appears to be central in the interaction with STIM1, the role of the N terminus and pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bergsmann, Judith, Derler, Isabella, Muik, Martin, Frischauf, Irene, Fahrner, Marc, Pollheimer, Philipp, Schwarzinger, Clemens, Gruber, Hermann J., Groschner, Klaus, Romanin, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173129/ https://www.ncbi.nlm.nih.gov/pubmed/21724845 http://dx.doi.org/10.1074/jbc.M111.227546

Ejemplares similares

Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating
por: Frischauf, Irene, et al.
Publicado: (2011)

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
por: Derler, Isabella, et al.
Publicado: (2018)

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
por: Derler, Isabella, et al.
Publicado: (2013)

Communication between N terminus and loop2 tunes Orai activation
por: Fahrner, Marc, et al.
Publicado: (2018)

Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca(2+) Influx
por: Schindl, Rainer, et al.
Publicado: (2012)

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)
por: Fahrner, Marc, et al.
Publicado: (2014)

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
por: Muik, Martin, et al.
Publicado: (2011)

Understanding How Components of a Ca(2+) Release-activated Ca(2+) Channel Function♦: The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
Publicado: (2013)

P2X Receptor Chimeras Highlight Roles of the Amino Terminus to Partial Agonist Efficacy, the Carboxyl Terminus to Recovery from Desensitization, and Independent Regulation of Channel Transitions
por: Allsopp, Rebecca C., et al.
Publicado: (2013)

Cell-Cell Contact Formation Governs Ca(2+) Signaling by TRPC4 in the Vascular Endothelium: EVIDENCE FOR A REGULATORY TRPC4-β-CATENIN INTERACTION
por: Graziani, Annarita, et al.
Publicado: (2010)

The STIM1/Orai signaling machinery
por: Fahrner, Marc, et al.
Publicado: (2013)

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF
por: Yuan, Jimin, et al.
Publicado: (2018)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca(2+) Signals
por: Brailoiu, Eugen, et al.
Publicado: (2010)

Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?
por: Schwarzer, Sarah, et al.
Publicado: (2010)

Molecularly Distinct Routes of Mitochondrial Ca(2+) Uptake Are Activated Depending on the Activity of the Sarco/Endoplasmic Reticulum Ca(2+) ATPase (SERCA)
por: Waldeck-Weiermair, Markus, et al.
Publicado: (2013)

Cysteine Scanning Mutagenesis (Residues Glu(52)–Gly(96)) of the Human P2X1 Receptor for ATP: MAPPING AGONIST BINDING AND CHANNEL GATING
por: Allsopp, Rebecca C., et al.
Publicado: (2011)

Modulation of Voltage- and Ca(2+)-dependent Gating of Ca(V)1.3 L-type Calcium Channels by Alternative Splicing of a C-terminal Regulatory Domain
por: Singh, Anamika, et al.
Publicado: (2008)

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells
por: Madl, Josef, et al.
Publicado: (2010)

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions
por: Tiffner, Adéla, et al.
Publicado: (2020)

Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C: FEEDBACK, HETEROGENEITY, AND GATING
por: Perrett, Rebecca M, et al.
Publicado: (2013)

Heat Shock Protein 90 Inhibitors Reduce Trafficking of ATP-gated P2X1 Receptors and Human Platelet Responsiveness
por: Lalo, Ulyana, et al.
Publicado: (2012)

N Terminus Is Key to the Dominant Negative Suppression of Ca(V)2 Calcium Channels: IMPLICATIONS FOR EPISODIC ATAXIA TYPE 2
por: Page, Karen M., et al.
Publicado: (2010)

Reengineering the Collision Coupling and Diffusion Mode of the A(2A)-adenosine Receptor: PALMITOYLATION IN HELIX 8 RELIEVES CONFINEMENT
por: Keuerleber, Simon, et al.
Publicado: (2012)

Recruitment of a Cytoplasmic Chaperone Relay by the A(2A) Adenosine Receptor
por: Bergmayr, Christian, et al.
Publicado: (2013)

Inhibition of the Cardiac Na(+) Channel Nav1.5 by Carbon Monoxide
por: Elies, Jacobo, et al.
Publicado: (2014)

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding
por: Telezhkin, Vsevolod, et al.
Publicado: (2012)

Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation
por: Hooper, Robert, et al.
Publicado: (2011)

Canonical Transient Receptor Potential 6 (TRPC6), a Redox-regulated Cation Channel
por: Graham, Sarabeth, et al.
Publicado: (2010)

Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function
por: Terry, Lara E., et al.
Publicado: (2021)

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH
por: Lu, Yingying, et al.
Publicado: (2013)

Molecular mechanisms of STIM/Orai communication
por: Derler, Isabella, et al.
Publicado: (2016)

Increase in Serum Ca(2+/)Mg(2+) Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels
por: Sun, Yuyang, et al.
Publicado: (2013)

Depletion of plasma membrane–associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg(2+), spermine, and pH
por: Zhelay, Tetyana, et al.
Publicado: (2018)

Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc
por: Haller, Martina, et al.
Publicado: (2016)

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4
por: Shukla, Arun K., et al.
Publicado: (2010)

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA–mDia2 signaling and filopodium formation
por: Argenzio, Elisabetta, et al.
Publicado: (2018)

Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements
por: Smit, Judith J., et al.
Publicado: (2013)

Ca(2+) Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors
por: Alswied, Abdullah, et al.
Publicado: (2015)

Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-1 (NEDD4-1) Controls the Sorting of Newly Synthesized Ca(V)1.2 Calcium Channels
por: Rougier, Jean-Sebastien, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jb3tp4jroac09uvj4i39gbegf1