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Mining Endonuclease Cleavage Determinants in Genomic Sequence Data

Homing endonucleases have great potential as tools for targeted gene therapy and gene correction, but identifying variants of these enzymes capable of cleaving specific DNA targets of interest is necessary before the widespread use of such technologies is possible. We identified homologues of the LA...

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Detalles Bibliográficos
Autores principales:	Szeto, Mindy D., Boissel, Sandrine J. S., Baker, David, Thyme, Summer B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173205/ https://www.ncbi.nlm.nih.gov/pubmed/21778233 http://dx.doi.org/10.1074/jbc.M111.259572

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