Cargando…

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway

The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand cross-links. At the heart of this pathway is the monoubiquitination of the FANCI-FANCD2 (ID) complex by the multiprotein “core complex” containing the E3 ubiquitin ligase FANCL. Vertebrate organisms have the eight-protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hodson, Charlotte, Cole, Ambrose R., Lewis, Laurence P. C., Miles, Jennifer A., Purkiss, Andrew, Walden, Helen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173227/ https://www.ncbi.nlm.nih.gov/pubmed/21775430 http://dx.doi.org/10.1074/jbc.M111.244632

Ejemplares similares

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL
por: Miles, Jennifer A., et al.
Publicado: (2015)

The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex
por: Cole, Ambrose R., et al.
Publicado: (2010)

Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection
por: Hodson, Charlotte, et al.
Publicado: (2014)

Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase
por: Spratt, Donald E., et al.
Publicado: (2012)

Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination
por: Liu, Jin, et al.
Publicado: (2011)

Structural analysis of the LDL receptor–interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site
por: Martinelli, Luca, et al.
Publicado: (2020)

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases
por: Canning, Peter, et al.
Publicado: (2013)

Impact of altered phosphorylation on loss of function of juvenile Parkinsonism–associated genetic variants of the E3 ligase parkin
por: Aguirre, Jacob D., et al.
Publicado: (2018)

Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold
por: Stieglitz, Benjamin, et al.
Publicado: (2012)

Determinants of Small Ubiquitin-like Modifier 1 (SUMO1) Protein Specificity, E3 Ligase, and SUMO-RanGAP1 Binding Activities of Nucleoporin RanBP2
por: Gareau, Jaclyn R., et al.
Publicado: (2012)

Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55
por: Gao, Chen, et al.
Publicado: (2019)

Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens
por: Savva, Christos G., et al.
Publicado: (2013)

Trimeric Structure of (+)-Pinoresinol-forming Dirigent Protein at 1.95 Å Resolution with Three Isolated Active Sites
por: Kim, Kye-Won, et al.
Publicado: (2015)

Pterocarpan synthase (PTS) structures suggest a common quinone methide–stabilizing function in dirigent proteins and proteins with dirigent-like domains
por: Meng, Qingyan, et al.
Publicado: (2020)

Apolipoprotein E4 Domain Interaction Induces Endoplasmic Reticulum Stress and Impairs Astrocyte Function
por: Zhong, Ning, et al.
Publicado: (2009)

Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli
por: Pilipczuk, Justyna, et al.
Publicado: (2017)

Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces
por: Moore, Benjamin, et al.
Publicado: (2011)

Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME
por: Bacik, John-Paul, et al.
Publicado: (2010)

A Common Theme in Interaction of Bacterial Immunoglobulin-binding Proteins with Immunoglobulins Illustrated in the Equine System
por: Lewis, Melanie J., et al.
Publicado: (2008)

Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses
por: Holm, Tobias, et al.
Publicado: (2018)

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17
por: Dean, Dexter N., et al.
Publicado: (2020)

Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway
por: Cornwell, Matthew J., et al.
Publicado: (2019)

Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement
por: Miller, Ami, et al.
Publicado: (2012)

A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel
por: Arcario, Mark J., et al.
Publicado: (2017)

Palmitoylation-induced Aggregation of Cysteine-string Protein Mutants That Cause Neuronal Ceroid Lipofuscinosis
por: Greaves, Jennifer, et al.
Publicado: (2012)

Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis
por: Guhaniyogi, Jayita, et al.
Publicado: (2009)

Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin β-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6
por: Pereira, Jose Henrique, et al.
Publicado: (2016)

Low Resolution Structure and Dynamics of a Colicin-Receptor Complex Determined by Neutron Scattering
por: Clifton, Luke A., et al.
Publicado: (2012)

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease
por: McGlinchey, Ryan P., et al.
Publicado: (2019)

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
por: Min, Xiaoshan, et al.
Publicado: (2018)

Evidence That GH115 α-Glucuronidase Activity, Which Is Required to Degrade Plant Biomass, Is Dependent on Conformational Flexibility
por: Rogowski, Artur, et al.
Publicado: (2014)

Organization of Subunits in the Membrane Domain of the Bovine F-ATPase Revealed by Covalent Cross-linking
por: Lee, Jennifer, et al.
Publicado: (2015)

Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain
por: Salvage, Samantha C., et al.
Publicado: (2019)

N-terminal Domain of Prion Protein Directs Its Oligomeric Association
por: Trevitt, Clare R., et al.
Publicado: (2014)

Evidence for Steric Regulation of Fibrinogen Binding to Staphylococcus aureus Fibronectin-binding Protein A (FnBPA)
por: Stemberk, Vaclav, et al.
Publicado: (2014)

Towards a Molecular Understanding of the Fanconi Anemia Core Complex
por: Hodson, Charlotte, et al.
Publicado: (2012)

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations
por: Hocking, Henry G., et al.
Publicado: (2008)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells
por: Gomes, Mariana P. B., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_dch1v9v2ddqb0v7armbsrpnprj