Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

As STAT5 is critical for the differentiation, proliferation, and survival of progenitor B cells, this transcription factor may play a role in acute lymphoblastic leukemia (ALL). Here, we show increased expression of activated signal transducer and activator of transcription 5 (STAT5), which is corre...

Descripción completa

Detalles Bibliográficos
Autores principales: Heltemes-Harris, Lynn M., Willette, Mark J.L., Ramsey, Laura B., Qiu, Yi Hua, Neeley, E. Shannon, Zhang, Nianxiang, Thomas, Deborah A., Koeuth, Thearith, Baechler, Emily C., Kornblau, Steven M., Farrar, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173246/
https://www.ncbi.nlm.nih.gov/pubmed/21606506
http://dx.doi.org/10.1084/jem.20101947

Ejemplares similares

Ejemplares similares