Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver

BACKGROUND: Traditional assessment of drug-induced hepatotoxicity includes morphological examination of the liver and evaluation of liver enzyme activity in serum. The objective of the study was to determine the origin of drug-related elevation in serum alanine aminotransferase (ALT) activity in the...

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Detalles Bibliográficos
Autores principales: Fuentealba, Carmen, Bera, Monali, Jessen, Bart, Sace, Fred, Stevens, Greg J, Trajkovic, Dusko, Yang, Amy H, Evering, Winston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173283/
https://www.ncbi.nlm.nih.gov/pubmed/21846403
http://dx.doi.org/10.1186/1476-5926-10-8

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