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Subcoronary versus supracoronary aortic stenosis. an experimental evaluation

BACKGROUND: Valvular aortic stenosis is the most common cause of left ventricular hypertrophy due to gradually increasing pressure work. As the stenosis develop the left ventricular hypertrophy may lead to congestive heart failure, increased risk of perioperative complications and also increased ris...

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Autores principales: Sorensen, Mette, Hasenkam, J Michael, Jensen, Henrik, Sloth, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173302/
https://www.ncbi.nlm.nih.gov/pubmed/21859468
http://dx.doi.org/10.1186/1749-8090-6-100
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author Sorensen, Mette
Hasenkam, J Michael
Jensen, Henrik
Sloth, Erik
author_facet Sorensen, Mette
Hasenkam, J Michael
Jensen, Henrik
Sloth, Erik
author_sort Sorensen, Mette
collection PubMed
description BACKGROUND: Valvular aortic stenosis is the most common cause of left ventricular hypertrophy due to gradually increasing pressure work. As the stenosis develop the left ventricular hypertrophy may lead to congestive heart failure, increased risk of perioperative complications and also increased risk of sudden death. A functional porcine model imitating the pathophysiological nature of valvular aortic stenosis is very much sought after in order to study the geometrical and pathophysiological changes of the left ventricle, timing of surgery and also pharmacological therapy in this patient group. Earlier we developed a porcine model for aortic stenosis based on supracoronary aortic banding, this model may not completely imitate the pathophysiological changes that occurs when valvular aortic stenosis is present including the coronary blood flow. It would therefore be desirable to optimize this model according to the localization of the stenosis. METHODS: In 20 kg pigs subcoronary (n = 8), supracoronary aortic banding (n = 8) or sham operation (n = 4) was preformed via a left lateral thoracotomy. The primary endpoint was left ventricular wall thickness; secondary endpoints were heart/body weight ratio and the systolic/diastolic blood flow ratio in the left anterior descending coronary. Statistical evaluation by oneway anova and unpaired t-test. RESULTS: Sub- and supracoronary banding induce an equal degree of left ventricular hypertrophy compared with the control group. The coronary blood flow ratio was slightly but not significantly higher in the supracoronary group (ratio = 0.45) compared with the two other groups (subcoronary ratio = 0.36, control ratio = 0.34). CONCLUSIONS: A human pathophysiologically compatible porcine model for valvular aortic stenosis was developed by performing subcoronary aortic banding. Sub- and supracoronary aortic banding induce an equal degree of left ventricular hypertrophy. This model may be valid for experimental investigations of aortic valve stenosis but studies of left ventricular hypertrophy can be studied equally well by graduated constriction of the ascending aorta.
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spelling pubmed-31733022011-09-15 Subcoronary versus supracoronary aortic stenosis. an experimental evaluation Sorensen, Mette Hasenkam, J Michael Jensen, Henrik Sloth, Erik J Cardiothorac Surg Research Article BACKGROUND: Valvular aortic stenosis is the most common cause of left ventricular hypertrophy due to gradually increasing pressure work. As the stenosis develop the left ventricular hypertrophy may lead to congestive heart failure, increased risk of perioperative complications and also increased risk of sudden death. A functional porcine model imitating the pathophysiological nature of valvular aortic stenosis is very much sought after in order to study the geometrical and pathophysiological changes of the left ventricle, timing of surgery and also pharmacological therapy in this patient group. Earlier we developed a porcine model for aortic stenosis based on supracoronary aortic banding, this model may not completely imitate the pathophysiological changes that occurs when valvular aortic stenosis is present including the coronary blood flow. It would therefore be desirable to optimize this model according to the localization of the stenosis. METHODS: In 20 kg pigs subcoronary (n = 8), supracoronary aortic banding (n = 8) or sham operation (n = 4) was preformed via a left lateral thoracotomy. The primary endpoint was left ventricular wall thickness; secondary endpoints were heart/body weight ratio and the systolic/diastolic blood flow ratio in the left anterior descending coronary. Statistical evaluation by oneway anova and unpaired t-test. RESULTS: Sub- and supracoronary banding induce an equal degree of left ventricular hypertrophy compared with the control group. The coronary blood flow ratio was slightly but not significantly higher in the supracoronary group (ratio = 0.45) compared with the two other groups (subcoronary ratio = 0.36, control ratio = 0.34). CONCLUSIONS: A human pathophysiologically compatible porcine model for valvular aortic stenosis was developed by performing subcoronary aortic banding. Sub- and supracoronary aortic banding induce an equal degree of left ventricular hypertrophy. This model may be valid for experimental investigations of aortic valve stenosis but studies of left ventricular hypertrophy can be studied equally well by graduated constriction of the ascending aorta. BioMed Central 2011-08-22 /pmc/articles/PMC3173302/ /pubmed/21859468 http://dx.doi.org/10.1186/1749-8090-6-100 Text en Copyright ©2011 Sorensen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sorensen, Mette
Hasenkam, J Michael
Jensen, Henrik
Sloth, Erik
Subcoronary versus supracoronary aortic stenosis. an experimental evaluation
title Subcoronary versus supracoronary aortic stenosis. an experimental evaluation
title_full Subcoronary versus supracoronary aortic stenosis. an experimental evaluation
title_fullStr Subcoronary versus supracoronary aortic stenosis. an experimental evaluation
title_full_unstemmed Subcoronary versus supracoronary aortic stenosis. an experimental evaluation
title_short Subcoronary versus supracoronary aortic stenosis. an experimental evaluation
title_sort subcoronary versus supracoronary aortic stenosis. an experimental evaluation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173302/
https://www.ncbi.nlm.nih.gov/pubmed/21859468
http://dx.doi.org/10.1186/1749-8090-6-100
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