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Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer

BACKGROUND: PI3K and mTOR are key components of signal transduction pathways critical for cell survival. Numerous PI3K inhibitors have entered clinical trials, while mTOR is the target of approved drugs for metastatic renal cell carcinoma (RCC). We characterized expression of p85 and p110α PI3K subu...

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Detalles Bibliográficos
Autores principales:	Elfiky, Aymen A, Aziz, Saadia A, Conrad, Patricia J, Siddiqui, Summar, Hackl, Wolfgang, Maira, Michel, Robert, Camp L, Kluger, Harriet M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173341/ https://www.ncbi.nlm.nih.gov/pubmed/21834980 http://dx.doi.org/10.1186/1479-5876-9-133

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