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MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay
BACKGROUND AND AIMS: During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragmen...
Autores principales: | Veidal, Sanne Skovgård, Karsdal, Morten Asser, Vassiliadis, Efstathios, Nawrocki, Arkadiusz, Larsen, Martin Røssel, Nguyen, Quoc Hai Trieu, Hägglund, Per, Luo, Yunyun, Zheng, Qinlong, Vainer, Ben, Leeming, Diana Julie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173456/ https://www.ncbi.nlm.nih.gov/pubmed/21935455 http://dx.doi.org/10.1371/journal.pone.0024753 |
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