Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a

Cyclooxygenase-2 (COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway...

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Detalles Bibliográficos
Autores principales: Carlson, Mary L, Wilson, Ellen T, Prescott, Stephen M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317356/
https://www.ncbi.nlm.nih.gov/pubmed/14675489
http://dx.doi.org/10.1186/1476-4598-2-42
Descripción
Sumario:Cyclooxygenase-2 (COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1. Recently shown to be essential for transformation via the c-Myc pathway, Pontin52/TIP49a promotes COX-2 expression in tissue culture and is overexpressed in colon cancer tissue, co-localizing with COX-2 expression in transformed tissue, relative to paired normal tissue.

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