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Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression

The effects of Leishmania mexicana metacyclic promastigotes upon MAP kinase signalling in mouse bone marrow macrophages and subsequent expression of the disease regulatory proteins iNOS and COX-2 were studied. At a ratio of 5:1, promastigotes caused a marked increase in phosphorylation of the three...

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Detalles Bibliográficos
Autores principales:	Shweash, Muhannad, Adrienne McGachy, H., Schroeder, Juliane, Neamatallah, Thikryat, Bryant, Clare E., Millington, Owain, Mottram, Jeremy C., Alexander, James, Plevin, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173610/ https://www.ncbi.nlm.nih.gov/pubmed/21664694 http://dx.doi.org/10.1016/j.molimm.2011.05.013

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