Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers

We compared structure and function of EDL and Soleus muscles in adult (4–6 m) mice lacking both Calsequestrin (CASQ) isoforms, the main SR Ca(2+)-binding proteins. Lack of CASQ induced ultrastructural alterations in ~30% of Soleus fibers, but not in EDL. Twitch time parameters were prolonged in both...

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Detalles Bibliográficos
Autores principales: Paolini, Cecilia, Quarta, Marco, D'Onofrio, Laura, Reggiani, Carlo, Protasi, Feliciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173739/
https://www.ncbi.nlm.nih.gov/pubmed/21941434
http://dx.doi.org/10.1155/2011/634075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173739/
https://www.ncbi.nlm.nih.gov/pubmed/21941434
http://dx.doi.org/10.1155/2011/634075

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