An Intracytoplasmic IL-10 Receptor Variant Permits Rapid Reduction in STAT3 Activation

Within the IL10R1 gene two common variants are associated with certain diseases: SNP3, a serine-138-to-glycine mutation is in linkage disequilibrium with SNP4, a glycine-330-to-arginine mutation, both of which are considered loss-of-function alleles. However, the molecular consequence of G330R is un...

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Detalles Bibliográficos
Autores principales: Finsterbusch, Michaela, Khare, Vineeta, Campregher, Christoph, Evstatiev, Rayko, Gasche, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173877/
https://www.ncbi.nlm.nih.gov/pubmed/21654841
http://dx.doi.org/10.1038/gene.2011.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173877/
https://www.ncbi.nlm.nih.gov/pubmed/21654841
http://dx.doi.org/10.1038/gene.2011.12

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