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Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

BACKGROUND: The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. MATERIALS AND METHODS: Forty rats were divided into f...

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Autores principales: Böyük, Abdullah, Önder, Akin, Kapan, Murat, Gümüş, Metehan, Fιrat, Uğur, Başaralι, Mustafa Kemal, Alp, Harun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173897/
https://www.ncbi.nlm.nih.gov/pubmed/21969793
http://dx.doi.org/10.4103/0973-1296.84236
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author Böyük, Abdullah
Önder, Akin
Kapan, Murat
Gümüş, Metehan
Fιrat, Uğur
Başaralι, Mustafa Kemal
Alp, Harun
author_facet Böyük, Abdullah
Önder, Akin
Kapan, Murat
Gümüş, Metehan
Fιrat, Uğur
Başaralι, Mustafa Kemal
Alp, Harun
author_sort Böyük, Abdullah
collection PubMed
description BACKGROUND: The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. MATERIALS AND METHODS: Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy. RESULTS: TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group. CONCLUSION: These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.
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spelling pubmed-31738972011-10-03 Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion Böyük, Abdullah Önder, Akin Kapan, Murat Gümüş, Metehan Fιrat, Uğur Başaralι, Mustafa Kemal Alp, Harun Pharmacogn Mag Original Article BACKGROUND: The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. MATERIALS AND METHODS: Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy. RESULTS: TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group. CONCLUSION: These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3173897/ /pubmed/21969793 http://dx.doi.org/10.4103/0973-1296.84236 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Böyük, Abdullah
Önder, Akin
Kapan, Murat
Gümüş, Metehan
Fιrat, Uğur
Başaralι, Mustafa Kemal
Alp, Harun
Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
title Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
title_full Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
title_fullStr Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
title_full_unstemmed Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
title_short Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
title_sort ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173897/
https://www.ncbi.nlm.nih.gov/pubmed/21969793
http://dx.doi.org/10.4103/0973-1296.84236
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