T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study

BACKGROUND: Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept. MATERIALS AND METHODS: Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immun...

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Detalles Bibliográficos
Autor principal: Wiwanitkit, Viroj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173908/
https://www.ncbi.nlm.nih.gov/pubmed/21977079
http://dx.doi.org/10.4103/1817-1745.84398
Descripción
Sumario:BACKGROUND: Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept. MATERIALS AND METHODS: Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique. RESULTS: Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2. CONCLUSION: After complete manipulation on EPHA2 molecules, the five best epitopes were derived.

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