T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study

BACKGROUND: Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept. MATERIALS AND METHODS: Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immun...

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Detalles Bibliográficos
Autor principal: Wiwanitkit, Viroj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173908/
https://www.ncbi.nlm.nih.gov/pubmed/21977079
http://dx.doi.org/10.4103/1817-1745.84398
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author Wiwanitkit, Viroj
author_facet Wiwanitkit, Viroj
author_sort Wiwanitkit, Viroj
collection PubMed
description BACKGROUND: Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept. MATERIALS AND METHODS: Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique. RESULTS: Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2. CONCLUSION: After complete manipulation on EPHA2 molecules, the five best epitopes were derived.
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spelling pubmed-31739082011-10-04 T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study Wiwanitkit, Viroj J Pediatr Neurosci Original Article BACKGROUND: Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept. MATERIALS AND METHODS: Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique. RESULTS: Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2. CONCLUSION: After complete manipulation on EPHA2 molecules, the five best epitopes were derived. Medknow Publications 2011 /pmc/articles/PMC3173908/ /pubmed/21977079 http://dx.doi.org/10.4103/1817-1745.84398 Text en © Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wiwanitkit, Viroj
T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study
title T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study
title_full T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study
title_fullStr T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study
title_full_unstemmed T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study
title_short T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study
title_sort t-cell epitope finding on epha2 for further glioma vaccine development: an immunomics study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173908/
https://www.ncbi.nlm.nih.gov/pubmed/21977079
http://dx.doi.org/10.4103/1817-1745.84398
work_keys_str_mv AT wiwanitkitviroj tcellepitopefindingonepha2forfurthergliomavaccinedevelopmentanimmunomicsstudy

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