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A novel strategy for exploring the reassortment origins of newly emerging influenza virus

In early 2009, new swine-origin influenza A (H1N1) virus emerged in Mexico and the United States. The emerging influenza virus had made global influenza pandemic for nearly one year. To every emerging pathogen, exploring the origin sources is vital for viral control and clearance. Influenza virus is...

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Detalles Bibliográficos
Autores principales: Tian, Deqiao, Wang, Yumin, Zheng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174038/
https://www.ncbi.nlm.nih.gov/pubmed/21938207
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author Tian, Deqiao
Wang, Yumin
Zheng, Tao
author_facet Tian, Deqiao
Wang, Yumin
Zheng, Tao
author_sort Tian, Deqiao
collection PubMed
description In early 2009, new swine-origin influenza A (H1N1) virus emerged in Mexico and the United States. The emerging influenza virus had made global influenza pandemic for nearly one year. To every emerging pathogen, exploring the origin sources is vital for viral control and clearance. Influenza virus is different from other virus in that it has 8 segments, making the segment reassortment a main drive in virus evolution. In exploring reassortment evolution origins of a newly emerging influenza virus, integrated comparing of the origin sources of all the segments is necessary. If some segments have high homologous with one parental strain, lower homologous with another parental strain, while other segments are reverse, can we proposed that this emerging influenza virus may re-assort from the two parental strains. Here we try to explore the multilevel reassortment evolution origins of 2009 H1N1 influenza virus using this method. By further validating the fidelity of this strategy, this method might be useful in judging the reassortment origins of newly emerging influenza virus.
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spelling pubmed-31740382011-09-21 A novel strategy for exploring the reassortment origins of newly emerging influenza virus Tian, Deqiao Wang, Yumin Zheng, Tao Bioinformation Hypothesis In early 2009, new swine-origin influenza A (H1N1) virus emerged in Mexico and the United States. The emerging influenza virus had made global influenza pandemic for nearly one year. To every emerging pathogen, exploring the origin sources is vital for viral control and clearance. Influenza virus is different from other virus in that it has 8 segments, making the segment reassortment a main drive in virus evolution. In exploring reassortment evolution origins of a newly emerging influenza virus, integrated comparing of the origin sources of all the segments is necessary. If some segments have high homologous with one parental strain, lower homologous with another parental strain, while other segments are reverse, can we proposed that this emerging influenza virus may re-assort from the two parental strains. Here we try to explore the multilevel reassortment evolution origins of 2009 H1N1 influenza virus using this method. By further validating the fidelity of this strategy, this method might be useful in judging the reassortment origins of newly emerging influenza virus. Biomedical Informatics 2011-09-06 /pmc/articles/PMC3174038/ /pubmed/21938207 Text en © 2011 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Tian, Deqiao
Wang, Yumin
Zheng, Tao
A novel strategy for exploring the reassortment origins of newly emerging influenza virus
title A novel strategy for exploring the reassortment origins of newly emerging influenza virus
title_full A novel strategy for exploring the reassortment origins of newly emerging influenza virus
title_fullStr A novel strategy for exploring the reassortment origins of newly emerging influenza virus
title_full_unstemmed A novel strategy for exploring the reassortment origins of newly emerging influenza virus
title_short A novel strategy for exploring the reassortment origins of newly emerging influenza virus
title_sort novel strategy for exploring the reassortment origins of newly emerging influenza virus
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174038/
https://www.ncbi.nlm.nih.gov/pubmed/21938207
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