Cargando…

Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms

AF4 belongs to a family of proteins implicated in childhood lymphoblastic leukaemia, FRAXE (Fragile X E site) mental retardation and ataxia. AF4 is a transcriptional activator that is involved in transcriptional elongation. Although AF4 has been implicated in MLL (mixed-lineage leukaemia)-related le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Esposito, Gabriella, Cevenini, Armando, Cuomo, Alessandro, de Falco, Francesca, Sabbatino, Dario, Pane, Fabrizio, Ruoppolo, Margherita, Salvatore, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174057/ https://www.ncbi.nlm.nih.gov/pubmed/21574958 http://dx.doi.org/10.1042/BJ20101633

Ejemplares similares

MiR‐27a downregulates 14‐3‐3θ, RUNX1, AF4, and MLL‐AF4, crucial drivers of blast transformation in t(4;11) leukemia cells
por: Fioretti, Tiziana, et al.
Publicado: (2022)

Symptomatic and Asymptomatic Patients in the Polish Atrial Fibrillation (POL-AF) Registry
por: Kiliszek, Marek, et al.
Publicado: (2021)

Nuclear FGFR2 Interacts with the MLL-AF4 Oncogenic Chimera and Positively Regulates HOXA9 Gene Expression in t(4;11) Leukemia Cells
por: Fioretti, Tiziana, et al.
Publicado: (2021)

Enhancer SINEs Link Pol III to Pol II Transcription in Neurons
por: Policarpi, Cristina, et al.
Publicado: (2017)

COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
por: Costanzo, Michele, et al.
Publicado: (2022)

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
por: Guo, Yang Eric, et al.
Publicado: (2019)

Gene-specific RNA pol II phosphorylation and the "CTD code"
por: Kim, Hyunmin, et al.
Publicado: (2010)

Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis
por: Peddu, Chandana, et al.
Publicado: (2018)

Label-Free Quantitative Proteomics in a Methylmalonyl-CoA Mutase-Silenced Neuroblastoma Cell Line
por: Costanzo, Michele, et al.
Publicado: (2018)

Chromatin remodeling by Pol II primes efficient Pol III transcription
por: Yague-Sanz, Carlo, et al.
Publicado: (2023)

Hyperuricemia as a Marker of Reduced Left Ventricular Ejection Fraction in Patients with Atrial Fibrillation: Results of the POL-AF Registry Study
por: Wełnicki, Marcin, et al.
Publicado: (2021)

Molecular Characterization of Choroideremia-Associated Deletions Reveals an Unexpected Regulation of CHM Gene Transcription
por: Fioretti, Tiziana, et al.
Publicado: (2021)

Dataset of a comparative proteomics experiment in a methylmalonyl-CoA mutase knockout HEK 293 cell model
por: Costanzo, Michele, et al.
Publicado: (2020)

Proteomics Reveals that Methylmalonyl-CoA Mutase Modulates Cell Architecture and Increases Susceptibility to Stress
por: Costanzo, Michele, et al.
Publicado: (2020)

Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD
por: Koga, Mitsunori, et al.
Publicado: (2015)

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
por: Gelot, Camille, et al.
Publicado: (2023)

Trends in the Prescription of Non-Vitamin K Antagonist Oral Anticoagulants for Atrial Fibrillation: Results of the Polish Atrial Fibrillation (POL-AF) Registry
por: Gorczyca, Iwona, et al.
Publicado: (2020)

Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle
por: Bertoletti, Federica, et al.
Publicado: (2017)

PolG Inhibits Gastric Cancer Glycolysis and Viability by Suppressing PKM2 Phosphorylation
por: Lv, Mengzhu, et al.
Publicado: (2021)

Characteristics and Treatment of Atrial Fibrillation with Respect to the Presence or Absence of Heart Failure. Insights from the Multicenter Polish Atrial Fibrillation (POL-AF) Registry
por: Gawałko, Monika, et al.
Publicado: (2021)

Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort
por: Wełnicki, Marcin, et al.
Publicado: (2022)

Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III
por: Jiang, Yongpeng, et al.
Publicado: (2020)

The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repair
por: Shimada, Kenji, et al.
Publicado: (2021)

Human cytomegalovirus RNA2.7 inhibits RNA polymerase II (Pol II) Serine-2 phosphorylation by reducing the interaction between Pol II and phosphorylated cyclin-dependent kinase 9 (pCDK9)
por: Huang, Yujing, et al.
Publicado: (2022)

Multi-Omics Studies Unveil Extraciliary Functions of BBS10 and Show Metabolic Aberrations Underlying Renal Disease in Bardet–Biedl Syndrome
por: Marchese, Emanuela, et al.
Publicado: (2022)

The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis
por: Boldinova, Elizaveta O, et al.
Publicado: (2023)

Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry
por: Szpotowicz, Anna, et al.
Publicado: (2021)

Do Patients with Atrial Fibrillation and a History of Ischemic Stroke Overuse Reduced Doses of NOACs?—Results of the Polish Atrial Fibrillation (POL-AF) Registry
por: Szyszkowska, Anna, et al.
Publicado: (2022)

Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity
por: de Walque, Stéphane, et al.
Publicado: (2006)

Transcription factor binding aites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity
por: de Walque, Stéphane, et al.
Publicado: (2006)

Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity
por: Goffin, Véronique, et al.
Publicado: (2005)

AFS Monitoring: The CERN AFS Console
por: Wiebalck, Arne
Publicado: (2008)

E2F1-dependent methyl cap formation requires RNA pol II phosphorylation
por: Aregger, Michael, et al.
Publicado: (2012)

A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation
por: Dronamraju, Raghuvar, et al.
Publicado: (2014)

Mug{AF}amar{AF}at Farn{AF}ats{AF}i == Farnatchi au bal masqué == Farnatchi at the masked ball /
por: Fayard, Roland
Publicado: (1997)

Specialization versus conservation: How Pol I and Pol III use the conserved architecture of the pre-initiation complex for specialized transcription
por: Hoffmann, Niklas A., et al.
Publicado: (2016)

Overophedning af partikelaccelerator var frygtet af forskere
Publicado: (2008)

Expression of concern on ‘transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity’
Publicado: (2023)

HIV Pol Inhibits HIV Budding and Mediates the Severe Budding Defect of Gag-Pol
por: Gan, Xin, et al.
Publicado: (2012)

Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells
por: Marchese, Emanuela, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g4tbo2d894e5c9e9fn356ngkp1