Cargando…

Immune Modulation through 4-1BB Enhances SIV Vaccine Protection in Non-Human Primates against SIVmac251 Challenge

Costimulatory molecules play a central role in the development of cellular immunity. Understanding how costimulatory pathways can be directed to positively influence the immune response may be critical for the generation of an effective HIV vaccine. Here, we evaluated the ability of intravenous admi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hirao, Lauren A., Hokey, David A., Morrow, Matthew P., Jure-Kunkel, Maria N., Weiner, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174159/ https://www.ncbi.nlm.nih.gov/pubmed/21935390 http://dx.doi.org/10.1371/journal.pone.0024250

Ejemplares similares

P19-49. Modulation of vaccine induced responses through CTLA-4 and 41BB enhances protection in macaques following SIVmac251 challenge
por: Hirao, LA, et al.
Publicado: (2009)

SIV escape mutants in rhesus macaques vaccinated with NEF-derived lipopeptides and challenged with pathogenic SIVmac251
por: Villefroy, Pascale, et al.
Publicado: (2006)

Intra-dermal immunisation with SIV gag-based vaccines alone inhibits acquisition of SIVmac251
por: Almond, N, et al.
Publicado: (2012)

Location and Dynamics of the Immunodominant CD8 T Cell Response to SIVΔnef Immunization and SIVmac251 Vaginal Challenge
por: Sasikala-Appukuttan, Arun K., et al.
Publicado: (2013)

P03-11. DNA vaccination with IL-12 lowers viral replication following SIVmac251 challenge
por: Hirao, LA, et al.
Publicado: (2009)

Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
por: Abdulhaqq, Shaheed A., et al.
Publicado: (2019)

Preservation of a subset of SIV-specific central memory CD4+ T cells correlates with control of viremia in SIVmac251 infected macaques
por: Felber, Barbara K, et al.
Publicado: (2006)

Characterization in rabbits & nonhuman primates of the neutralizing antibody response elicited by DNA & protein vaccination with SIVmac251 & SIVsmE660
por: Menon, VP, et al.
Publicado: (2012)

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
por: Whitney, James B., et al.
Publicado: (2018)

Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251
por: Mattathil, Jeffy G., et al.
Publicado: (2023)

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIV(mac)251 Challenge
por: Alpert, Michael D., et al.
Publicado: (2012)

Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques
por: Mannioui, Abdelkrim, et al.
Publicado: (2009)

Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals
por: Greenier, Jennifer L, et al.
Publicado: (2005)

Immunotherapy with DNA vaccine and live attenuated rubella/SIV gag vectors plus early ART can prevent SIVmac251 viral rebound in acutely infected rhesus macaques
por: Virnik, Konstantin, et al.
Publicado: (2020)

Antibodies to the envelope protein protect macaques from SIVmac251 acquisition in an immunization regimen that mimics the RV-144 Thai trial
por: Franchini, G, et al.
Publicado: (2012)

Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIV(mac251) Rectal Challenge
por: Tuero, Iskra, et al.
Publicado: (2015)

P16-36. Functional genomic immune profile of SIV DNA vaccines delivered by electroporation and combined with molecular adjuvants
por: Boyer, JD, et al.
Publicado: (2009)

Chronic Morphine Administration Differentially Modulates Viral Reservoirs in a Simian Immunodeficiency Virus SIVmac251-Infected Rhesus Macaque Model
por: Acharya, Arpan, et al.
Publicado: (2021)

P14-08. Intramuscular DNA delivery by electroporation leads to greatly enhanced systemic and mucosal immune responses and control of SIVmac251 challenge
por: Pavlakis, GN, et al.
Publicado: (2009)

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques
por: Abreu, Celina M., et al.
Publicado: (2019)

P20-13. Identification and characterization of early founder populations in Rhesus macaques vaginally infected with SIVmac251
por: Stone, M, et al.
Publicado: (2009)

Early Divergent Host Responses in SHIVsf162P3 and SIVmac251 Infected Macaques Correlate with Control of Viremia
por: Xu, Huanbin, et al.
Publicado: (2011)

Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques
por: Lewis, MG, et al.
Publicado: (2010)

P03-08. Protection against SIVmac239 challenge in a rhesus macaque model conferred by a doxycycline dependent attenuated SIVmac239
por: Page, M, et al.
Publicado: (2009)

A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products
por: Shin, Young C., et al.
Publicado: (2018)

Correlates of Protection Against SIV(mac251) Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors
por: Tuyishime, Steven, et al.
Publicado: (2018)

Mapping of SIVmac T-cell epitopes in cynomolgus macaques immunized with auxo-GTU-MultiSIV DNA by the intradermal route followed by electroporation
por: Corneau, A, et al.
Publicado: (2012)

Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against SIVmac239 wild-type challenge in a rhesus macaque model
por: Berry, Neil, et al.
Publicado: (2009)

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1
por: Keele, Brandon F., et al.
Publicado: (2009)

Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques
por: Gonzalez-Nieto, Lucas, et al.
Publicado: (2019)

A Multiplex Microsphere-Based Immunoassay Increases the Sensitivity of SIV-Specific Antibody Detection in Serum Samples and Mucosal Specimens Collected from Rhesus Macaques Infected with SIVmac239
por: Powell, Rebecca L.R., et al.
Publicado: (2013)

Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIV(mac251) acquisition in macaques
por: Rahman, Mohammad Arif, et al.
Publicado: (2023)

OA06-02. Monospecific expansion of SIVmac251 during acute infection masks multiple transmitted virus variants revealed during the chronic phase
por: Felber, BK, et al.
Publicado: (2009)

Complete Genome Sequence of a Reference Stock of Simian Immunodeficiency Virus RNA (SIVmac251/32H/L28) Determined by Deep Sequencing
por: Jenkins, Adrian, et al.
Publicado: (2016)

Increased immunogenicity of HIV vaccination with constant-current electroporation and molecular adjuvants in mice and rhesus macaques
por: Hirao, Lauren, et al.
Publicado: (2006)

Engagement of monocytes, NK cells, and CD4(+) Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIV(mac251) vaginal acquisition
por: Gorini, Giacomo, et al.
Publicado: (2020)

Low autocrine interferon beta production as a gene therapy approach for AIDS: Infusion of interferon beta-engineered lymphocytes in macaques chronically infected with SIVmac251
por: Gay, Wilfried, et al.
Publicado: (2004)

GM-CSF co-expressing DNA/MVA vaccine, prevention of acquisition by two series of SIVE660 challenges followed by a series of SIV251 challenges
por: Robinson, H, et al.
Publicado: (2012)

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity
por: Fuchs, Sebastian P., et al.
Publicado: (2015)

Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys
por: Lim, So-Yon, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_fijhgkphramtd9ftpua7qn1ndb