Molecular Determinants of Interactions between the N-Terminal Domain and the Transmembrane Core That Modulate hERG K(+) Channel Gating

A conserved eag domain in the cytoplasmic amino terminus of the human ether-a-go-go-related gene (hERG) potassium channel is critical for its slow deactivation gating. Introduction of gene fragments encoding the eag domain are able to restore normal deactivation properties of channels from which mos...

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Detalles Bibliográficos
Autores principales: Fernández-Trillo, Jorge, Barros, Francisco, Machín, Angeles, Carretero, Luis, Domínguez, Pedro, de la Peña, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174182/
https://www.ncbi.nlm.nih.gov/pubmed/21935437
http://dx.doi.org/10.1371/journal.pone.0024674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174182/
https://www.ncbi.nlm.nih.gov/pubmed/21935437
http://dx.doi.org/10.1371/journal.pone.0024674

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