Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

Metaphyseal chondrodysplasia, Schmid type (MCDS) is characterized by mild short stature and growth plate hypertrophic zone expansion, and caused by collagen X mutations. We recently demonstrated the central importance of ER stress in the pathology of MCDS by recapitulating the disease phenotype by e...

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Detalles Bibliográficos
Autores principales: Cameron, Trevor L., Bell, Katrina M., Tatarczuch, Liliana, Mackie, Eleanor J., Rajpar, M. Helen, McDermott, Ben T., Boot-Handford, Raymond P., Bateman, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174197/
https://www.ncbi.nlm.nih.gov/pubmed/21935428
http://dx.doi.org/10.1371/journal.pone.0024600

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