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Virtual High-Throughput Screening Identifies Mycophenolic Acid as a Novel RNA Capping Inhibitor

The RNA guanylyltransferase (GTase) is involved in the synthesis of the (m7)Gppp-RNA cap structure found at the 5′ end of eukaryotic mRNAs. GTases are members of the covalent nucleotidyl transferase superfamily, which also includes DNA and RNA ligases. GTases catalyze a two-step reaction in which th...

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Detalles Bibliográficos
Autores principales:	Tremblay-Létourneau, Maude, Despins, Simon, Bougie, Isabelle, Bisaillon, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174198/ https://www.ncbi.nlm.nih.gov/pubmed/21935470 http://dx.doi.org/10.1371/journal.pone.0024806

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