Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation

PMEL is an amyloidogenic protein that appears to be exclusively expressed in pigment cells and forms intralumenal fibrils within early stage melanosomes upon which eumelanins deposit in later stages. PMEL is well conserved among vertebrates, and allelic variants in several species are associated wit...

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Detalles Bibliográficos
Autores principales: Hellström, Anders R., Watt, Brenda, Fard, Shahrzad Shirazi, Tenza, Danièle, Mannström, Paula, Narfström, Kristina, Ekesten, Björn, Ito, Shosuke, Wakamatsu, Kazumasa, Larsson, Jimmy, Ulfendahl, Mats, Kullander, Klas, Raposo, Graça, Kerje, Susanne, Hallböök, Finn, Marks, Michael S., Andersson, Leif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174228/
https://www.ncbi.nlm.nih.gov/pubmed/21949658
http://dx.doi.org/10.1371/journal.pgen.1002285

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