Cargando…
The Tissue-Specific Rep8/UBXD6 Tethers p97 to the Endoplasmic Reticulum Membrane for Degradation of Misfolded Proteins
The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors. In addition, p97 plays a central role in degradation of misfolded s...
Autores principales: | Madsen, Louise, Kriegenburg, Franziska, Vala, Andrea, Best, Diana, Prag, Søren, Hofmann, Kay, Seeger, Michael, Adams, Ian R., Hartmann-Petersen, Rasmus |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174242/ https://www.ncbi.nlm.nih.gov/pubmed/21949850 http://dx.doi.org/10.1371/journal.pone.0025061 |
Ejemplares similares
-
The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions
por: Braxton, Julian R., et al.
Publicado: (2023) -
UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy
por: Bento, Ana C., et al.
Publicado: (2018) -
Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect
por: Madsen, Louise, et al.
Publicado: (2014) -
Misfolding and aggregation of newly synthesized proteins in the endoplasmic reticulum
Publicado: (1992) -
The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes
por: Wu, Shuangcheng Alivia, et al.
Publicado: (2023)