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Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys

We examined recently neuronal substrates for predictive pursuit using a memory-based smooth pursuit task that distinguishes the discharge related to memory of visual motion-direction from that related to movement preparation. We found that the supplementary eye fields (SEF) contain separate signals...

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Autores principales: Kurkin, Sergei, Akao, Teppei, Shichinohe, Natsuko, Fukushima, Junko, Fukushima, Kikuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174374/
https://www.ncbi.nlm.nih.gov/pubmed/21837438
http://dx.doi.org/10.1007/s00221-011-2825-6
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author Kurkin, Sergei
Akao, Teppei
Shichinohe, Natsuko
Fukushima, Junko
Fukushima, Kikuro
author_facet Kurkin, Sergei
Akao, Teppei
Shichinohe, Natsuko
Fukushima, Junko
Fukushima, Kikuro
author_sort Kurkin, Sergei
collection PubMed
description We examined recently neuronal substrates for predictive pursuit using a memory-based smooth pursuit task that distinguishes the discharge related to memory of visual motion-direction from that related to movement preparation. We found that the supplementary eye fields (SEF) contain separate signals coding memory and assessment of visual motion-direction, decision not-to-pursue, and preparation for pursuit. Since medial superior temporal area (MST) is essential for visual motion processing and projects to SEF, we examined whether MST carried similar signals. We analyzed the discharge of 108 MSTd neurons responding to visual motion stimuli. The majority (69/108 = 64%) were also modulated during smooth pursuit. However, in nearly all (104/108 = 96%) of the MSTd neurons tested, there was no significant discharge modulation during the delay periods that required memory of visual motion-direction or preparation for smooth pursuit or not-to-pursue. Only 4 neurons of the 108 (4%) exhibited significantly higher discharge rates during the delay periods; however, their responses were non-directional and not instruction specific. Representative signals in the MSTd clearly differed from those in the SEF during memory-based smooth pursuit. MSTd neurons are unlikely to provide signals for memory of visual motion-direction or preparation for smooth pursuit eye movements.
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spelling pubmed-31743742011-09-26 Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys Kurkin, Sergei Akao, Teppei Shichinohe, Natsuko Fukushima, Junko Fukushima, Kikuro Exp Brain Res Research Article We examined recently neuronal substrates for predictive pursuit using a memory-based smooth pursuit task that distinguishes the discharge related to memory of visual motion-direction from that related to movement preparation. We found that the supplementary eye fields (SEF) contain separate signals coding memory and assessment of visual motion-direction, decision not-to-pursue, and preparation for pursuit. Since medial superior temporal area (MST) is essential for visual motion processing and projects to SEF, we examined whether MST carried similar signals. We analyzed the discharge of 108 MSTd neurons responding to visual motion stimuli. The majority (69/108 = 64%) were also modulated during smooth pursuit. However, in nearly all (104/108 = 96%) of the MSTd neurons tested, there was no significant discharge modulation during the delay periods that required memory of visual motion-direction or preparation for smooth pursuit or not-to-pursue. Only 4 neurons of the 108 (4%) exhibited significantly higher discharge rates during the delay periods; however, their responses were non-directional and not instruction specific. Representative signals in the MSTd clearly differed from those in the SEF during memory-based smooth pursuit. MSTd neurons are unlikely to provide signals for memory of visual motion-direction or preparation for smooth pursuit eye movements. Springer-Verlag 2011-08-12 2011 /pmc/articles/PMC3174374/ /pubmed/21837438 http://dx.doi.org/10.1007/s00221-011-2825-6 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Research Article
Kurkin, Sergei
Akao, Teppei
Shichinohe, Natsuko
Fukushima, Junko
Fukushima, Kikuro
Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys
title Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys
title_full Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys
title_fullStr Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys
title_full_unstemmed Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys
title_short Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys
title_sort neuronal activity in medial superior temporal area (mst) during memory-based smooth pursuit eye movements in monkeys
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174374/
https://www.ncbi.nlm.nih.gov/pubmed/21837438
http://dx.doi.org/10.1007/s00221-011-2825-6
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