Natural Form of Noncytolytic Flexible Human Fc as a Long-Acting Carrier of Agonistic Ligand, Erythropoietin

Human IgG1 Fc has been widely used as a bioconjugate, but exhibits shortcomings, such as antibody- and complement-mediated cytotoxicity as well as decreased bioactivity, when applied to agonistic proteins. Here, we constructed a nonimmunogenic, noncytolytic and flexible hybrid Fc (hyFc) consisting o...

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Detalles Bibliográficos
Autores principales: Im, Se Jin, Yang, Sang In, Yang, Se Hwan, Choi, Dong Hoon, Choi, So Young, Kim, Hea Sook, Jang, Do Soo, Jin, Kyeong Sik, Chung, Yo-Kyung, Kim, Seung-Hee, Paik, Sang Hoon, Park, Yoo Chang, Chung, Moon Koo, Kim, Yong Bum, Han, Kang-Hyun, Choi, Kwan Yong, Sung, Young Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174958/
https://www.ncbi.nlm.nih.gov/pubmed/21957455
http://dx.doi.org/10.1371/journal.pone.0024574

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