Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis

The expression of selected microRNAs (miRNAs) known to be involved in the regulation of immune responses was analyzed in 74 patients with relapsing remitting multiple sclerosis (RRMS) and 32 healthy controls. Four miRNAs (miR-326, miR-155, miR-146a, miR-142-3p) were aberrantly expressed in periphera...

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Autores principales: Waschbisch, Anne, Atiya, Monika, Linker, Ralf A., Potapov, Sergej, Schwab, Stefan, Derfuss, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174971/
https://www.ncbi.nlm.nih.gov/pubmed/21949733
http://dx.doi.org/10.1371/journal.pone.0024604
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author Waschbisch, Anne
Atiya, Monika
Linker, Ralf A.
Potapov, Sergej
Schwab, Stefan
Derfuss, Tobias
author_facet Waschbisch, Anne
Atiya, Monika
Linker, Ralf A.
Potapov, Sergej
Schwab, Stefan
Derfuss, Tobias
author_sort Waschbisch, Anne
collection PubMed
description The expression of selected microRNAs (miRNAs) known to be involved in the regulation of immune responses was analyzed in 74 patients with relapsing remitting multiple sclerosis (RRMS) and 32 healthy controls. Four miRNAs (miR-326, miR-155, miR-146a, miR-142-3p) were aberrantly expressed in peripheral blood mononuclear cells from RRMS patients compared to controls. Although expression of these selected miRNAs did not differ between treatment-naïve (n = 36) and interferon-beta treated RRMS patients (n = 18), expression of miR-146a and miR-142-3p was significantly lower in glatiramer acetate (GA) treated RRMS patients (n = 20) suggesting that GA, at least in part, restores the expression of deregulated miRNAs in MS.
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spelling pubmed-31749712011-09-26 Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis Waschbisch, Anne Atiya, Monika Linker, Ralf A. Potapov, Sergej Schwab, Stefan Derfuss, Tobias PLoS One Research Article The expression of selected microRNAs (miRNAs) known to be involved in the regulation of immune responses was analyzed in 74 patients with relapsing remitting multiple sclerosis (RRMS) and 32 healthy controls. Four miRNAs (miR-326, miR-155, miR-146a, miR-142-3p) were aberrantly expressed in peripheral blood mononuclear cells from RRMS patients compared to controls. Although expression of these selected miRNAs did not differ between treatment-naïve (n = 36) and interferon-beta treated RRMS patients (n = 18), expression of miR-146a and miR-142-3p was significantly lower in glatiramer acetate (GA) treated RRMS patients (n = 20) suggesting that GA, at least in part, restores the expression of deregulated miRNAs in MS. Public Library of Science 2011-09-16 /pmc/articles/PMC3174971/ /pubmed/21949733 http://dx.doi.org/10.1371/journal.pone.0024604 Text en Waschbisch et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Waschbisch, Anne
Atiya, Monika
Linker, Ralf A.
Potapov, Sergej
Schwab, Stefan
Derfuss, Tobias
Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis
title Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis
title_full Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis
title_fullStr Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis
title_full_unstemmed Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis
title_short Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis
title_sort glatiramer acetate treatment normalizes deregulated microrna expression in relapsing remitting multiple sclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174971/
https://www.ncbi.nlm.nih.gov/pubmed/21949733
http://dx.doi.org/10.1371/journal.pone.0024604
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