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Simultaneous Inhibition of mTOR-Containing Complex 1 (mTORC1) and MNK Induces Apoptosis of Cutaneous T-Cell Lymphoma (CTCL) Cells

BACKGROUND: mTOR kinase forms the mTORC1 complex by associating with raptor and other proteins and affects a number of key cell functions. mTORC1 activates p70S6kinase 1 (p70S6K1) and inhibits 4E-binding protein 1 (4E-BP1). In turn, p70S6K1 phosphorylates a S6 protein of the 40S ribosomal subunit (S...

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Detalles Bibliográficos
Autores principales:	Marzec, Michal, Liu, Xiaobin, Wysocka, Maria, Rook, Alain H., Odum, Niels, Wasik, Mariusz A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174990/ https://www.ncbi.nlm.nih.gov/pubmed/21949767 http://dx.doi.org/10.1371/journal.pone.0024849

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