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Is respiratory viral infection really an important trigger of asthma exacerbations in children?
We performed a prospective cohort study from September 2003 to December 2004 to delineate attributing the effect of different respiratory viral infections including newly discovered ones to asthma exacerbations in children in Hong Kong. One hundred and fourteen children aged 6–14 years with chronic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175036/ https://www.ncbi.nlm.nih.gov/pubmed/21448631 http://dx.doi.org/10.1007/s00431-011-1446-1 |
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author | Lee, So-lun Chiu, Shui-seng Susan Malik, Peiris Joseph S. Chan, Kwok-hung Wong, Hing-sang Wilfred Lau, Yu-lung |
author_facet | Lee, So-lun Chiu, Shui-seng Susan Malik, Peiris Joseph S. Chan, Kwok-hung Wong, Hing-sang Wilfred Lau, Yu-lung |
author_sort | Lee, So-lun |
collection | PubMed |
description | We performed a prospective cohort study from September 2003 to December 2004 to delineate attributing the effect of different respiratory viral infections including newly discovered ones to asthma exacerbations in children in Hong Kong. One hundred and fourteen children aged 6–14 years with chronic stable asthma and on regular inhaled steroid were monitored for respiratory symptoms over a full calendar year from recruitment. They would attend the study clinic if peak expiratory flow rate decreased to below 80% of their baselines, if they met a predefined symptom score, or if parents subjectively felt them developing a cold. Virological diagnosis using virus culture, antigen detection, and polymerase chain reaction methods on nasal swab specimens would be attempted for all these visits irrespective of triggers. Physician diagnosed outcome of each episode was documented. Three hundred and five episodes of respiratory illnesses were captured in the cohort. Nasal specimens were available in 166 episodes, 92 of which were diagnosed as asthma exacerbations, and 74 non-asthma related episodes. Respiratory viruses were detected in 61 of 166 episodes (36.7%). There was no significant difference in virus detection rate between asthma exacerbations (32 out of 97 episodes, 34.8%) and non-asthma respiratory illnesses (29 out of 79 episodes, 39.2%). Although newly discovered respiratory viruses were identified in these episodes, rhinovirus was the commonest organism associated with both asthma exacerbations and non-asthma related episodes. Plausible explanations for much lower virus detection rate than previously reported include improved personal hygiene and precautionary measures taken during respiratory tract infections in the immediate post-severe acute respiratory syndrome period together with a significant contribution of other adverse factors like environmental air pollution. We conclude that not all viral infections in children with asthma lead to an asthma exacerbation and the attributing effect of different triggers of asthma exacerbations in children vary across different time periods and across different localities. |
format | Online Article Text |
id | pubmed-3175036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-31750362011-09-26 Is respiratory viral infection really an important trigger of asthma exacerbations in children? Lee, So-lun Chiu, Shui-seng Susan Malik, Peiris Joseph S. Chan, Kwok-hung Wong, Hing-sang Wilfred Lau, Yu-lung Eur J Pediatr Original Paper We performed a prospective cohort study from September 2003 to December 2004 to delineate attributing the effect of different respiratory viral infections including newly discovered ones to asthma exacerbations in children in Hong Kong. One hundred and fourteen children aged 6–14 years with chronic stable asthma and on regular inhaled steroid were monitored for respiratory symptoms over a full calendar year from recruitment. They would attend the study clinic if peak expiratory flow rate decreased to below 80% of their baselines, if they met a predefined symptom score, or if parents subjectively felt them developing a cold. Virological diagnosis using virus culture, antigen detection, and polymerase chain reaction methods on nasal swab specimens would be attempted for all these visits irrespective of triggers. Physician diagnosed outcome of each episode was documented. Three hundred and five episodes of respiratory illnesses were captured in the cohort. Nasal specimens were available in 166 episodes, 92 of which were diagnosed as asthma exacerbations, and 74 non-asthma related episodes. Respiratory viruses were detected in 61 of 166 episodes (36.7%). There was no significant difference in virus detection rate between asthma exacerbations (32 out of 97 episodes, 34.8%) and non-asthma respiratory illnesses (29 out of 79 episodes, 39.2%). Although newly discovered respiratory viruses were identified in these episodes, rhinovirus was the commonest organism associated with both asthma exacerbations and non-asthma related episodes. Plausible explanations for much lower virus detection rate than previously reported include improved personal hygiene and precautionary measures taken during respiratory tract infections in the immediate post-severe acute respiratory syndrome period together with a significant contribution of other adverse factors like environmental air pollution. We conclude that not all viral infections in children with asthma lead to an asthma exacerbation and the attributing effect of different triggers of asthma exacerbations in children vary across different time periods and across different localities. Springer-Verlag 2011-03-30 2011 /pmc/articles/PMC3175036/ /pubmed/21448631 http://dx.doi.org/10.1007/s00431-011-1446-1 Text en © The Author(s) 2011 Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Paper Lee, So-lun Chiu, Shui-seng Susan Malik, Peiris Joseph S. Chan, Kwok-hung Wong, Hing-sang Wilfred Lau, Yu-lung Is respiratory viral infection really an important trigger of asthma exacerbations in children? |
title | Is respiratory viral infection really an important trigger of asthma exacerbations in children? |
title_full | Is respiratory viral infection really an important trigger of asthma exacerbations in children? |
title_fullStr | Is respiratory viral infection really an important trigger of asthma exacerbations in children? |
title_full_unstemmed | Is respiratory viral infection really an important trigger of asthma exacerbations in children? |
title_short | Is respiratory viral infection really an important trigger of asthma exacerbations in children? |
title_sort | is respiratory viral infection really an important trigger of asthma exacerbations in children? |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175036/ https://www.ncbi.nlm.nih.gov/pubmed/21448631 http://dx.doi.org/10.1007/s00431-011-1446-1 |
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