c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

BACKGROUND: Anti-apoptotic signals induced downstream of HER2 are known to contribute to the resistance to current treatments of breast cancer cells that overexpress this member of the EGFR family. Whether or not some of these signals are also involved in tumor maintenance by counteracting constitut...

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Detalles Bibliográficos
Autores principales: Campone, Mario, Noël, Bélinda, Couriaud, Cécile, Grau, Morgan, Guillemin, Yannis, Gautier, Fabien, Gouraud, Wilfried, Charbonnel, Catherine, Campion, Loïc, Jézéquel, Pascal, Braun, Frédérique, Barré, Benjamin, Coqueret, Olivier, Barillé-Nion, Sophie, Juin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175201/
https://www.ncbi.nlm.nih.gov/pubmed/21899728
http://dx.doi.org/10.1186/1476-4598-10-110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175201/
https://www.ncbi.nlm.nih.gov/pubmed/21899728
http://dx.doi.org/10.1186/1476-4598-10-110

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